A characteristic effect of pressure on the inclusion complexation of modified β-cyclodextrins with 4-substituted phenols

Yoshimi Sueishi, Tatsuhiro Ide

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The equilibrium constants for the inclusion complexation of two kinds of modified β-cyclodextrins (heptakis-(2,6-di-O-methyl)-β-cyclodextrin (DM-βCD) and heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-βCD)) with 4-substituted phenols were determined at high pressures. A characteristic pressure effect was found in the inclusion equilibria of modified β-CDs. As the external pressure increases, the inclusion equilibrium constants for the phenols/TM-βCD system increased remarkably, while the effect of pressure for the phenols/DM-βCD system was small. The reaction volumes for the CD inclusion complexation with 4-substituted phenols were estimated from the pressure dependence of the inclusion equilibria: ΔV = -14.9 ∼ -33.4 cm3 mol-1 for the phenols/TM-βCD system and -2.7 ∼ 8.6 cm3 mol-1 for the phenols/DM-βCD system. Analysis of the effect of pressure on the inclusion complexation with DM- and TM-βCDs revealed that there is a pressure-dependent competing complexation between included phenols and water molecules, and the number of water molecules included in the DM- and TM-βCD cavities in water was estimated.

Original languageEnglish
Pages (from-to)489-500
Number of pages12
JournalZeitschrift fur Physikalische Chemie
Volume219
Issue number4
DOIs
Publication statusPublished - May 18 2005

Keywords

  • Inclusion Complex
  • Modified Cyclodextrin
  • Phenols
  • Pressure Effect

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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