A Case report of primary Burkitt's lymphoma of the caecum

Koichi Nakagawa, Takahito Yagi, Nobutomo Moriya, Shinya Ohe, Masaaki Hashimoto, Hitoshi Ohtsuki

Research output: Contribution to journalArticle

Abstract

A 13-year-old boy was admitted to our hospital complaining of right lower quadrant pain. Barium enema and total colonoscopy discloseed a type 2'tumor in the caecum, which was histopathologically a Burkitt's lymphoma by biopsy. Computed tomography (CT), ultrasonography and 67Ga-scintigraphy demonstrated regional lymph node involvement. A right hemicolectomy with D 3+α lymph node dissection was performed. Histologically the tumor had a "starry sky" pattern, and immunophenotypical analysis showed that the neoplastic cells were CD10 antigen positive and CD21 antigen negative, suggesting of early B cell origin. Both immunoglobulin heavy chain and c-myc oncogene were found to be rearranged by southern blot analysis. On post-operative day 14, combined systemic chemotherapy (modified Japan Leukemia Study Group ALL-93 protocol) and intrathecal injection of MTX and Ara-C were given. There has been no sign of recurrence, as of 12 months after the surgery. The outcome of intestinal Burkitt's lymphoma is poor, because of frequency of a leukemic change or CNS relapse. Nonetheless, it was suggested that aggressive debulking of the tumor include an extensive resection of the lymphnodes (over D 3) and that intensive adjuvant chemotherapy may provide better prognosis in therapy to limit intestinal Burkitt's lymphoma.

Original languageEnglish
Pages (from-to)872-876
Number of pages5
JournalJapanese Journal of Gastroenterological Surgery
Volume30
Issue number4
Publication statusPublished - 1997

Fingerprint

Burkitt Lymphoma
Complement 3d Receptors
Recurrence
Neprilysin
Spinal Injections
Neoplasms
Immunoglobulin Heavy Chains
myc Genes
Cytarabine
Colonoscopy
Adjuvant Chemotherapy
Southern Blotting
Lymph Node Excision
Radionuclide Imaging
Ultrasonography
Japan
Leukemia
B-Lymphocytes
Lymph Nodes
Tomography

Keywords

  • Burkitt's lymphoma
  • Intestinal lymphoma

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

Cite this

Nakagawa, K., Yagi, T., Moriya, N., Ohe, S., Hashimoto, M., & Ohtsuki, H. (1997). A Case report of primary Burkitt's lymphoma of the caecum. Japanese Journal of Gastroenterological Surgery, 30(4), 872-876.

A Case report of primary Burkitt's lymphoma of the caecum. / Nakagawa, Koichi; Yagi, Takahito; Moriya, Nobutomo; Ohe, Shinya; Hashimoto, Masaaki; Ohtsuki, Hitoshi.

In: Japanese Journal of Gastroenterological Surgery, Vol. 30, No. 4, 1997, p. 872-876.

Research output: Contribution to journalArticle

Nakagawa, K, Yagi, T, Moriya, N, Ohe, S, Hashimoto, M & Ohtsuki, H 1997, 'A Case report of primary Burkitt's lymphoma of the caecum', Japanese Journal of Gastroenterological Surgery, vol. 30, no. 4, pp. 872-876.
Nakagawa K, Yagi T, Moriya N, Ohe S, Hashimoto M, Ohtsuki H. A Case report of primary Burkitt's lymphoma of the caecum. Japanese Journal of Gastroenterological Surgery. 1997;30(4):872-876.
Nakagawa, Koichi ; Yagi, Takahito ; Moriya, Nobutomo ; Ohe, Shinya ; Hashimoto, Masaaki ; Ohtsuki, Hitoshi. / A Case report of primary Burkitt's lymphoma of the caecum. In: Japanese Journal of Gastroenterological Surgery. 1997 ; Vol. 30, No. 4. pp. 872-876.
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