A Case report of primary Burkitt's lymphoma of the caecum

Koichi Nakagawa, Takahito Yagi, Nobutomo Moriya, Shinya Ohe, Masaaki Hashimoto, Hitoshi Ohtsuki

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A 13-year-old boy was admitted to our hospital complaining of right lower quadrant pain. Barium enema and total colonoscopy discloseed a type 2'tumor in the caecum, which was histopathologically a Burkitt's lymphoma by biopsy. Computed tomography (CT), ultrasonography and 67Ga-scintigraphy demonstrated regional lymph node involvement. A right hemicolectomy with D 3+α lymph node dissection was performed. Histologically the tumor had a "starry sky" pattern, and immunophenotypical analysis showed that the neoplastic cells were CD10 antigen positive and CD21 antigen negative, suggesting of early B cell origin. Both immunoglobulin heavy chain and c-myc oncogene were found to be rearranged by southern blot analysis. On post-operative day 14, combined systemic chemotherapy (modified Japan Leukemia Study Group ALL-93 protocol) and intrathecal injection of MTX and Ara-C were given. There has been no sign of recurrence, as of 12 months after the surgery. The outcome of intestinal Burkitt's lymphoma is poor, because of frequency of a leukemic change or CNS relapse. Nonetheless, it was suggested that aggressive debulking of the tumor include an extensive resection of the lymphnodes (over D 3) and that intensive adjuvant chemotherapy may provide better prognosis in therapy to limit intestinal Burkitt's lymphoma.

Original languageEnglish
Pages (from-to)872-876
Number of pages5
JournalJapanese Journal of Gastroenterological Surgery
Issue number4
Publication statusPublished - 1997



  • Burkitt's lymphoma
  • Intestinal lymphoma

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

Cite this

Nakagawa, K., Yagi, T., Moriya, N., Ohe, S., Hashimoto, M., & Ohtsuki, H. (1997). A Case report of primary Burkitt's lymphoma of the caecum. Japanese Journal of Gastroenterological Surgery, 30(4), 872-876.