A case report of highly advanced gastric cancer with ascites with long survival and improved QOL from combined chemotherapy of paclitaxel and 5-fluorouracil

Eiji Yamada, Motoki Ninomiya, Masahiko Nishizaki, Hiroshi Sasaki, Norihisa Takakura

Research output: Contribution to journalArticle

Abstract

The patient was a 63-year-old male who came to our hospital with the chief complaints of dyspepsia and abdominal fullness. Endoscopic findings showed Type 3 gastric cancer with pyloric stenosis. CT examination revealed a large amount of peritoneal fluid, invasion to the pancreas, peritoneal dissemination and paraaortic lymph node metastasis. Intraperitoneal administration of weekly CDDP 10 mg/body was in vain, and combined chemotherapy of paclitaxel and 5-fluorouracil was carried out. Ascites was significantly reduced and oral intake became possible two courses after this regimen. The tumor decreased in size after 3 courses, and the tumor markers returned to within normal limits. The patient was then discharged, and followed as an outpatient thereafter. Endoscopic examination showed improvement in narrowing of the antrum. However,tumor invasion to pancreas, peritoneal dissemination and lymph node metastasis relapsed. He died one year and one month after the onset.

Original languageEnglish
Pages (from-to)911-914
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume34
Issue number6
Publication statusPublished - Jun 2007
Externally publishedYes

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Paclitaxel
Ascites
Fluorouracil
Stomach Neoplasms
Pancreas
Lymph Nodes
Pyloric Stenosis
Neoplasm Metastasis
Drug Therapy
Survival
Dyspepsia
Ascitic Fluid
Tumor Biomarkers
Neoplasms
Outpatients

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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A case report of highly advanced gastric cancer with ascites with long survival and improved QOL from combined chemotherapy of paclitaxel and 5-fluorouracil. / Yamada, Eiji; Ninomiya, Motoki; Nishizaki, Masahiko; Sasaki, Hiroshi; Takakura, Norihisa.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 34, No. 6, 06.2007, p. 911-914.

Research output: Contribution to journalArticle

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