A case report of combined hepatocellular and cholangiocellular carcinoma with sarcomatous change that rapidly recurred to peritoneal dissemination after hepatectomy

Kinya Matsuoka, Ryuji Hirai, Tetsuya Ota, Masakazu Murakami, Hiroyoshi Doihara, Nobuyoshi Shimizu

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1 Citation (Scopus)

Abstract

We report a case of combined hepatocellular and cholangiocellular carcinoma with sarcomatous change that rapidly recurred in peritoneal dissemination after hepatectomy. A 58-year-old man referred for a liver mass was found in dynamic computed tomography (CT) and abdominal angiography to have a tumor with a diameter of 3cm not similar to hepatocellular carcinoma. Needle biopsy yielded a diagnosis was moderately differentiated hepatocellular carcinoma necessitating right hepatectomy of the liver. The 4. 0 × 3. 3 × 3. 2 cm tumor was an elastic hard, clear nodule without a capsule. Histologicaly it was combined hepatocellular and cholangiocellular carcinoma. On postoperative day (POD) 60, he was readmitted for abdominal distension and appetite loss. Abdominal CT showed peritoneal dissemination and accumulated ascites, cytological class V. After admission, his condition worsened rapidly and he died on POD 77 of peritoneal dissemination and peritonitis carcinomatosa. Microscopic findings of peritoneal dissemination on autopsy showed spindle cells and strange proliferated cells with a sarcomatous pattern. We believe these sarcomatous changes caused the rapid clinical course.

Original languageEnglish
Pages (from-to)1654-1658
Number of pages5
JournalJapanese Journal of Gastroenterological Surgery
Volume35
Issue number11
DOIs
Publication statusPublished - 2002

Keywords

  • Combined hepatocellular and cholangiocellular carcinoma
  • Hepatocellular carcinoma with sarcomatous change
  • Peritoneal dissemination

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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