Abstract
We report the case of a patient with advanced rectal cancer who achieved a pathological complete response to preoperative chemoradiotherapy (CRT). A 65-year-old man was diagnosed as having a two-thirds circumferential well- to moderately differentiated tumor (Rb-P, type 2). To control local recurrence, we treated the patient with CRT. Radiotherapy was administered in fractions of 2 Gy/day (total, 40 Gy). Concurrently, S-1 was administered orally at a fixed daily dose of 80 mg/m2 for 20 days. Withdrawal and/or dose reduction of S-1 was not necessary in spite of Grade 1 or 2 toxic effects, including diarrhea and periproctitis, occurring on day 7. Laparoscopic abdominoperineal resection was performed 6 weeks after the final dose of chemotherapy was administered. The histopathological regression grade was Grade 3. No recurrence was detected on enhanced CT more than 5 years after surgery. This case suggests that the regimen was both effective and tolerated, and that preoperative chemoradiotherapy may be effective for tumor suppression to prevent local recurrence.
Original language | English |
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Pages (from-to) | 381-384 |
Number of pages | 4 |
Journal | Japanese Journal of Cancer and Chemotherapy |
Volume | 43 |
Issue number | 3 |
Publication status | Published - Mar 2016 |
Externally published | Yes |
Keywords
- Chemoradiotherapy
- Rectal cancer
- S-1
ASJC Scopus subject areas
- Oncology
- Cancer Research