A case report of a pathological complete response of rectal cancer to preoperative chemoradiotherapy with tegafur

Tatsuya Morikawa, Fuminori Teraishi, Yasuo Shima, Jun Iwata

Research output: Contribution to journalArticle

Abstract

We report the case of a patient with advanced rectal cancer who achieved a pathological complete response to preoperative chemoradiotherapy (CRT). A 65-year-old man was diagnosed as having a two-thirds circumferential well- to moderately differentiated tumor (Rb-P, type 2). To control local recurrence, we treated the patient with CRT. Radiotherapy was administered in fractions of 2 Gy/day (total, 40 Gy). Concurrently, S-1 was administered orally at a fixed daily dose of 80 mg/m2 for 20 days. Withdrawal and/or dose reduction of S-1 was not necessary in spite of Grade 1 or 2 toxic effects, including diarrhea and periproctitis, occurring on day 7. Laparoscopic abdominoperineal resection was performed 6 weeks after the final dose of chemotherapy was administered. The histopathological regression grade was Grade 3. No recurrence was detected on enhanced CT more than 5 years after surgery. This case suggests that the regimen was both effective and tolerated, and that preoperative chemoradiotherapy may be effective for tumor suppression to prevent local recurrence.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume43
Issue number3
Publication statusPublished - Mar 2016
Externally publishedYes

Keywords

  • Chemoradiotherapy
  • Rectal cancer
  • S-1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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