A case of Wilson's disease with characteristic laparoscopic findings

Shin Ichiro Muro, Tetsuya Yasunaka, Nozomu Wada, Yuki Morimoto, Fusao Ikeda, Hidenori Shiraha, Akinobu Takaki, Kazuhiro Noso, Hiroaki Iwasaki, Kazuhide Yamamoto

Research output: Contribution to journalArticle

Abstract

A 44-year-old male was pointed out liver function abnormality by medical check-up. Blood examination and computed tomography showed liver cirrhosis. Then, he was referred to our hospital for further examination. After blood test, viral markers revealed previous infection of hepatitis B virus (HBV). We estimated the etiology of his liver disease as previous HBV infection. On laparoscopic examination, his liver surface was nodular with mixed yellowish nodules and ash gray to copper-colored nodules in the diameter of 3-10 mm. There were large regenerative nodules in segments 3 and 4. Large regenerative nodules and irregular steatosis were contradictory to HBV-related liver cirrhosis, so then we supposed Wilson's disease. The amount of copper excretion in the urine was 326.6 μg (>100 μg/24 h). After D-penicillamine administration, urinary copper excretion increased to 2151.5 μg/24 h. Though hepatic copper concentration was 174.5 μg/g wet tissue (>200 μg/g wet tissue), his laboratory data fulfilled the Leipzig diagnostic criteria proposed by EASL. Laparoscopic examination with liver biopsy has advantages to survey many disease-specific findings on liver surface and to obtain adequate liver sample. Laparoscopic examination is one of the effective procedures for diagnosing relatively rare liver disease like Wilson's disease.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalClinical Journal of Gastroenterology
Volume7
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Hepatolenticular Degeneration
Copper
Liver
Hepatitis B virus
Liver Cirrhosis
Liver Diseases
Penicillamine
Hematologic Tests
Virus Diseases
Rare Diseases
Biomarkers
Tomography
Urine
Biopsy
Infection

Keywords

  • Laparoscopy
  • Liver cirrhosis
  • Wilson's disease

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A case of Wilson's disease with characteristic laparoscopic findings. / Muro, Shin Ichiro; Yasunaka, Tetsuya; Wada, Nozomu; Morimoto, Yuki; Ikeda, Fusao; Shiraha, Hidenori; Takaki, Akinobu; Noso, Kazuhiro; Iwasaki, Hiroaki; Yamamoto, Kazuhide.

In: Clinical Journal of Gastroenterology, Vol. 7, No. 2, 2014, p. 175-179.

Research output: Contribution to journalArticle

Muro, Shin Ichiro ; Yasunaka, Tetsuya ; Wada, Nozomu ; Morimoto, Yuki ; Ikeda, Fusao ; Shiraha, Hidenori ; Takaki, Akinobu ; Noso, Kazuhiro ; Iwasaki, Hiroaki ; Yamamoto, Kazuhide. / A case of Wilson's disease with characteristic laparoscopic findings. In: Clinical Journal of Gastroenterology. 2014 ; Vol. 7, No. 2. pp. 175-179.
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