We report a case of systemic sclerosis complicated with antiphospholipid syndrome in a 50-year-old woman. She showed multiple signs and symptoms stich as sclerodactylia, a mask-like face, poikiloderma, multiple skin ulcers, interstitial pneumonia, sick sinus syndrome, and esophageal dysfunction. Both antinuclear antibody and lupus anticoagulant were positive. Initially we diagnosed her with systemic sclerosis. We treated the patient with prednisolone at a dose of 20-40 mg/day, and added steroid pulse therapy three times. Unfortunately, the patient died of pulmonary thromboembolism. We finally diagnosed her to have antiphospholipid antibody syndrome.
ASJC Scopus subject areas