A case of sublingual adenoid cystic carcinoma involving the mandible presenting as a “skip lesion”

Mariko Fujita, Yoshinobu Yanagi, Arthur R.G. Cortes, Emiko Saito Arita, Tomoo Onoda, Hitoshi Nagatsuka, Jun-Ichi Asaumi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with a propensity for perineural invasion. Microscopic invasion of ACC often prevents its detection on computed tomography (CT) or magnetic resonance imaging (MRI). We herein report a rare case of sublingual ACC presenting as a “skip lesion” that rapidly infiltrated the mandible after tumor resection. A 64-year-old man presented to Okayama University Hospital with an 18-month history of swelling in the right floor of the mouth. Clinical examination displayed an ulcerated swollen mass in that region. An enhanced mass was detected in the right sublingual space on CT and MRI. Bone surface erosion was observed at the inferior border of the mandible, but continuity with the sublingual mass or mass around that lesion was not detected by imaging. Sublingual tumor resection and selective neck dissection were performed by the pull-through method. Histopathologically, the surgical margins were free of cancer cells, and the tumor was diagnosed as ACC. Continuity with the sublingual mass and mandibular bone was not detected intraoperatively. However, marked bone resorption was detected in the anterior mandible 3 months after the operation. Biopsy was performed, and the findings indicated the same histological type of sublingual ACC. This case suggests that a malignant tumor close to the jaw bone requires the clinician to consider the possibility of bone invasion and to observe a wide region surrounding the tumor using imaging examination.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalOral Radiology
DOIs
Publication statusAccepted/In press - Nov 27 2017

Fingerprint

Adenoid Cystic Carcinoma
Mandible
Neoplasms
Bone and Bones
Tomography
Magnetic Resonance Imaging
Mouth Floor
Neck Dissection
Bone Resorption
Jaw
Biopsy

Keywords

  • Adenoid cystic carcinoma
  • Magnetic resonance imaging
  • Recurrence

ASJC Scopus subject areas

  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

A case of sublingual adenoid cystic carcinoma involving the mandible presenting as a “skip lesion”. / Fujita, Mariko; Yanagi, Yoshinobu; Cortes, Arthur R.G.; Arita, Emiko Saito; Onoda, Tomoo; Nagatsuka, Hitoshi; Asaumi, Jun-Ichi.

In: Oral Radiology, 27.11.2017, p. 1-7.

Research output: Contribution to journalArticle

@article{d2d40bfdb2f342a38a36a45758e4530e,
title = "A case of sublingual adenoid cystic carcinoma involving the mandible presenting as a “skip lesion”",
abstract = "Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with a propensity for perineural invasion. Microscopic invasion of ACC often prevents its detection on computed tomography (CT) or magnetic resonance imaging (MRI). We herein report a rare case of sublingual ACC presenting as a “skip lesion” that rapidly infiltrated the mandible after tumor resection. A 64-year-old man presented to Okayama University Hospital with an 18-month history of swelling in the right floor of the mouth. Clinical examination displayed an ulcerated swollen mass in that region. An enhanced mass was detected in the right sublingual space on CT and MRI. Bone surface erosion was observed at the inferior border of the mandible, but continuity with the sublingual mass or mass around that lesion was not detected by imaging. Sublingual tumor resection and selective neck dissection were performed by the pull-through method. Histopathologically, the surgical margins were free of cancer cells, and the tumor was diagnosed as ACC. Continuity with the sublingual mass and mandibular bone was not detected intraoperatively. However, marked bone resorption was detected in the anterior mandible 3 months after the operation. Biopsy was performed, and the findings indicated the same histological type of sublingual ACC. This case suggests that a malignant tumor close to the jaw bone requires the clinician to consider the possibility of bone invasion and to observe a wide region surrounding the tumor using imaging examination.",
keywords = "Adenoid cystic carcinoma, Magnetic resonance imaging, Recurrence",
author = "Mariko Fujita and Yoshinobu Yanagi and Cortes, {Arthur R.G.} and Arita, {Emiko Saito} and Tomoo Onoda and Hitoshi Nagatsuka and Jun-Ichi Asaumi",
year = "2017",
month = "11",
day = "27",
doi = "10.1007/s11282-017-0306-8",
language = "English",
pages = "1--7",
journal = "Oral Radiology",
issn = "0911-6028",
publisher = "Springer Japan",

}

TY - JOUR

T1 - A case of sublingual adenoid cystic carcinoma involving the mandible presenting as a “skip lesion”

AU - Fujita, Mariko

AU - Yanagi, Yoshinobu

AU - Cortes, Arthur R.G.

AU - Arita, Emiko Saito

AU - Onoda, Tomoo

AU - Nagatsuka, Hitoshi

AU - Asaumi, Jun-Ichi

PY - 2017/11/27

Y1 - 2017/11/27

N2 - Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with a propensity for perineural invasion. Microscopic invasion of ACC often prevents its detection on computed tomography (CT) or magnetic resonance imaging (MRI). We herein report a rare case of sublingual ACC presenting as a “skip lesion” that rapidly infiltrated the mandible after tumor resection. A 64-year-old man presented to Okayama University Hospital with an 18-month history of swelling in the right floor of the mouth. Clinical examination displayed an ulcerated swollen mass in that region. An enhanced mass was detected in the right sublingual space on CT and MRI. Bone surface erosion was observed at the inferior border of the mandible, but continuity with the sublingual mass or mass around that lesion was not detected by imaging. Sublingual tumor resection and selective neck dissection were performed by the pull-through method. Histopathologically, the surgical margins were free of cancer cells, and the tumor was diagnosed as ACC. Continuity with the sublingual mass and mandibular bone was not detected intraoperatively. However, marked bone resorption was detected in the anterior mandible 3 months after the operation. Biopsy was performed, and the findings indicated the same histological type of sublingual ACC. This case suggests that a malignant tumor close to the jaw bone requires the clinician to consider the possibility of bone invasion and to observe a wide region surrounding the tumor using imaging examination.

AB - Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with a propensity for perineural invasion. Microscopic invasion of ACC often prevents its detection on computed tomography (CT) or magnetic resonance imaging (MRI). We herein report a rare case of sublingual ACC presenting as a “skip lesion” that rapidly infiltrated the mandible after tumor resection. A 64-year-old man presented to Okayama University Hospital with an 18-month history of swelling in the right floor of the mouth. Clinical examination displayed an ulcerated swollen mass in that region. An enhanced mass was detected in the right sublingual space on CT and MRI. Bone surface erosion was observed at the inferior border of the mandible, but continuity with the sublingual mass or mass around that lesion was not detected by imaging. Sublingual tumor resection and selective neck dissection were performed by the pull-through method. Histopathologically, the surgical margins were free of cancer cells, and the tumor was diagnosed as ACC. Continuity with the sublingual mass and mandibular bone was not detected intraoperatively. However, marked bone resorption was detected in the anterior mandible 3 months after the operation. Biopsy was performed, and the findings indicated the same histological type of sublingual ACC. This case suggests that a malignant tumor close to the jaw bone requires the clinician to consider the possibility of bone invasion and to observe a wide region surrounding the tumor using imaging examination.

KW - Adenoid cystic carcinoma

KW - Magnetic resonance imaging

KW - Recurrence

UR - http://www.scopus.com/inward/record.url?scp=85035122422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85035122422&partnerID=8YFLogxK

U2 - 10.1007/s11282-017-0306-8

DO - 10.1007/s11282-017-0306-8

M3 - Article

C2 - 30484035

AN - SCOPUS:85035122422

SP - 1

EP - 7

JO - Oral Radiology

JF - Oral Radiology

SN - 0911-6028

ER -