A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita, Kenichiro Utida, Hitoshi Nagatsuka, Toshikazu Gondo, Kohsuke Sasaki, Yoshiya Ueyama

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

Original languageEnglish
Title of host publicationOral Oncology Extra
Pages170-173
Number of pages4
Volume41
Edition8
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Pleomorphic Adenoma
Comparative Genomic Hybridization
Palate
Squamous Cell Carcinoma
Carcinoma
Hard Palate
Salivary Glands
Coloring Agents
DNA
Neoplasms

Keywords

  • Comparative genomic hybridization
  • CXPA
  • Hard palate
  • Immunostain
  • Malignant transformation
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Oncology
  • Oral Surgery
  • Pathology and Forensic Medicine

Cite this

A case of squamous cell carcinoma ex pleomorphic adenoma in the palate : Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization. / Ita, Masamichi; Utida, Kenichiro; Nagatsuka, Hitoshi; Gondo, Toshikazu; Sasaki, Kohsuke; Ueyama, Yoshiya.

Oral Oncology Extra. Vol. 41 8. ed. 2005. p. 170-173.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ita, Masamichi ; Utida, Kenichiro ; Nagatsuka, Hitoshi ; Gondo, Toshikazu ; Sasaki, Kohsuke ; Ueyama, Yoshiya. / A case of squamous cell carcinoma ex pleomorphic adenoma in the palate : Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization. Oral Oncology Extra. Vol. 41 8. ed. 2005. pp. 170-173
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