Abstract
Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.
Original language | English |
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Pages (from-to) | 170-173 |
Number of pages | 4 |
Journal | Oral Oncology Extra |
Volume | 41 |
Issue number | 8 |
DOIs | |
Publication status | Published - Sep 2005 |
Externally published | Yes |
Keywords
- CXPA
- Comparative genomic hybridization
- Hard palate
- Immunostain
- Malignant transformation
- Squamous cell carcinoma
ASJC Scopus subject areas
- Oral Surgery
- Pathology and Forensic Medicine
- Otorhinolaryngology
- Oncology