Abstract
Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.
| Original language | English |
|---|---|
| Pages (from-to) | 170-173 |
| Number of pages | 4 |
| Journal | Oral Oncology Extra |
| Volume | 41 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Sep 1 2005 |
Keywords
- CXPA
- Comparative genomic hybridization
- Hard palate
- Immunostain
- Malignant transformation
- Squamous cell carcinoma
ASJC Scopus subject areas
- Oral Surgery
- Pathology and Forensic Medicine
- Otorhinolaryngology
- Oncology
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Cite this
Ita, M., Utida, K., Nagatsuka, H., Gondo, T., Sasaki, K., & Ueyama, Y. (2005). A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization. Oral Oncology Extra, 41(8), 170-173. https://doi.org/10.1016/j.ooe.2005.04.004