A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita; Kenichiro Utida; Hitoshi Nagatsuka; Toshikazu Gondo; Kohsuke Sasaki; Yoshiya Ueyama

doi:10.1016/j.ooe.2005.04.004

A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita, Kenichiro Utida, Hitoshi Nagatsuka, Toshikazu Gondo, Kohsuke Sasaki, Yoshiya Ueyama

Research output: Contribution to journal › Article

Abstract

Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

Original language	English
Pages (from-to)	170-173
Number of pages	4
Journal	Oral Oncology Extra
Volume	41
Issue number	8
DOIs	https://doi.org/10.1016/j.ooe.2005.04.004
Publication status	Published - Sep 1 2005

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Keywords

Comparative genomic hybridization
CXPA
Hard palate
Immunostain
Malignant transformation
Squamous cell carcinoma

ASJC Scopus subject areas

Oral Surgery
Pathology and Forensic Medicine
Otorhinolaryngology
Oncology

Cite this

Ita, M., Utida, K., Nagatsuka, H., Gondo, T., Sasaki, K., & Ueyama, Y. (2005). A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization. Oral Oncology Extra, 41(8), 170-173. https://doi.org/10.1016/j.ooe.2005.04.004

A case of squamous cell carcinoma ex pleomorphic adenoma in the palate : Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization. / Ita, Masamichi; Utida, Kenichiro; Nagatsuka, Hitoshi; Gondo, Toshikazu; Sasaki, Kohsuke; Ueyama, Yoshiya.

In: Oral Oncology Extra, Vol. 41, No. 8, 01.09.2005, p. 170-173.

Research output: Contribution to journal › Article

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abstract = "Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.",

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10.1016/j.ooe.2005.04.004