A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita, Kenichiro Utida, Hitoshi Nagatsuka, Toshikazu Gondo, Kohsuke Sasaki, Yoshiya Ueyama

Research output: Contribution to journalArticle


Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalOral Oncology Extra
Issue number8
Publication statusPublished - Sep 1 2005



  • Comparative genomic hybridization
  • CXPA
  • Hard palate
  • Immunostain
  • Malignant transformation
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oral Surgery
  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

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