A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita; Kenichiro Utida; Hitoshi Nagatsuka; Toshikazu Gondo; Kohsuke Sasaki; Yoshiya Ueyama

doi:10.1016/j.ooe.2005.04.004

A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Masamichi Ita, Kenichiro Utida, Hitoshi Nagatsuka, Toshikazu Gondo, Kohsuke Sasaki, Yoshiya Ueyama

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

Original language	English
Pages (from-to)	170-173
Number of pages	4
Journal	Oral Oncology Extra
Volume	41
Issue number	8
DOIs	https://doi.org/10.1016/j.ooe.2005.04.004
Publication status	Published - Sep 2005
Externally published	Yes

Keywords

CXPA
Comparative genomic hybridization
Hard palate
Immunostain
Malignant transformation
Squamous cell carcinoma

ASJC Scopus subject areas

Oral Surgery
Pathology and Forensic Medicine
Otorhinolaryngology
Oncology

Access to Document

10.1016/j.ooe.2005.04.004

Cite this

A case of squamous cell carcinoma ex pleomorphic adenoma in the palate : Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization. / Ita, Masamichi; Utida, Kenichiro; Nagatsuka, Hitoshi; Gondo, Toshikazu; Sasaki, Kohsuke; Ueyama, Yoshiya.

In: Oral Oncology Extra, Vol. 41, No. 8, 09.2005, p. 170-173.

Research output: Contribution to journal › Article › peer-review

@article{b5942cd14e5d4e7983dc78342044c6a7,

title = "A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization",

abstract = "Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.",

keywords = "CXPA, Comparative genomic hybridization, Hard palate, Immunostain, Malignant transformation, Squamous cell carcinoma",

author = "Masamichi Ita and Kenichiro Utida and Hitoshi Nagatsuka and Toshikazu Gondo and Kohsuke Sasaki and Yoshiya Ueyama",

year = "2005",

month = sep,

doi = "10.1016/j.ooe.2005.04.004",

language = "English",

volume = "41",

pages = "170--173",

journal = "Oral Oncology Extra",

issn = "1741-9409",

publisher = "Elsevier BV",

number = "8",

}

TY - JOUR

T1 - A case of squamous cell carcinoma ex pleomorphic adenoma in the palate

T2 - Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

AU - Ita, Masamichi

AU - Utida, Kenichiro

AU - Nagatsuka, Hitoshi

AU - Gondo, Toshikazu

AU - Sasaki, Kohsuke

AU - Ueyama, Yoshiya

PY - 2005/9

Y1 - 2005/9

N2 - Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

AB - Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.

KW - CXPA

KW - Comparative genomic hybridization

KW - Hard palate

KW - Immunostain

KW - Malignant transformation

KW - Squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=23944489288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944489288&partnerID=8YFLogxK

U2 - 10.1016/j.ooe.2005.04.004

DO - 10.1016/j.ooe.2005.04.004

M3 - Article

AN - SCOPUS:23944489288

VL - 41

SP - 170

EP - 173

JO - Oral Oncology Extra

JF - Oral Oncology Extra

SN - 1741-9409

IS - 8

ER -

A case of squamous cell carcinoma ex pleomorphic adenoma in the palate: Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this