Abstract
Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.
| Original language | English |
|---|---|
| Title of host publication | Oral Oncology Extra |
| Pages | 170-173 |
| Number of pages | 4 |
| Volume | 41 |
| Edition | 8 |
| DOIs | |
| Publication status | Published - Sep 2005 |
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Keywords
- Comparative genomic hybridization
- CXPA
- Hard palate
- Immunostain
- Malignant transformation
- Squamous cell carcinoma
ASJC Scopus subject areas
- Otorhinolaryngology
- Oncology
- Oral Surgery
- Pathology and Forensic Medicine
Cite this
A case of squamous cell carcinoma ex pleomorphic adenoma in the palate : Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization. / Ita, Masamichi; Utida, Kenichiro; Nagatsuka, Hitoshi; Gondo, Toshikazu; Sasaki, Kohsuke; Ueyama, Yoshiya.
Oral Oncology Extra. Vol. 41 8. ed. 2005. p. 170-173.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - A case of squamous cell carcinoma ex pleomorphic adenoma in the palate
T2 - Immunohistochemical analysis and chromosomal alteration by comparative genomic hybridization
AU - Ita, Masamichi
AU - Utida, Kenichiro
AU - Nagatsuka, Hitoshi
AU - Gondo, Toshikazu
AU - Sasaki, Kohsuke
AU - Ueyama, Yoshiya
PY - 2005/9
Y1 - 2005/9
N2 - Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.
AB - Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon tumor of salivary gland; moreover, histologically, squamous cell carcinoma (SCC) is exceedingly rare. This report documents a case of CXPA arising in the hard palate, which showed transformation from pleomorphic adenoma (PA) to SCC reacted to Ki-67 immunostaining. Other immunohistochemical stains also demonstrated different immunoreactivities between PA cells and SCC cells. Comparative genomic hybridization identified a chromosomal imbalance. Gain regions of the PA were 8q11-22 and 8q24 and the loss region was 13q32-34 in PA; additionally, in SCC, regions characterized by increased DNA copy number were 8p, 8q and 12q12-15.
KW - Comparative genomic hybridization
KW - CXPA
KW - Hard palate
KW - Immunostain
KW - Malignant transformation
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=23944489288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944489288&partnerID=8YFLogxK
U2 - 10.1016/j.ooe.2005.04.004
DO - 10.1016/j.ooe.2005.04.004
M3 - Chapter
AN - SCOPUS:23944489288
VL - 41
SP - 170
EP - 173
BT - Oral Oncology Extra
ER -