A case of small intestinal neuroendocrine carcinoma diagnosed using double-balloon endoscopy with long-term survival

Seiji Kawano, Yuichi Miyashima, Yoshio Miyabe, Yoshinari Kawai, Toshihiro Murata, Masashi Uda, Toshihiro Inokuchi, Hiroyuki Okada

Research output: Contribution to journalArticle

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Abstract

Neuroendocrine neoplasms, including neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs), are rare epithelial tumors with a predominant neuroendocrine differentiation. Compared with NETs, NECs have been reported to be rarer and have a poorer prognosis. We present a rare case of small bowel NEC diagnosed using double-balloon endoscopy (DBE) and the long-term survival accomplished via intensive therapy. DBE revealed an ulcerative tumor in the deep jejunum, and biopsy specimens showed large and highly dysplastic tumor cells; immuno-histological synaptophysin and chromogranin A tests were positive, and the Ki-67 index was more than 90%. Partial intestinal resection without complete lymph node dissection was performed and, postoperatively, chemotherapy was administered. The patient was observed for 3 years after chemotherapy, and complete remission was maintained.

LanguageEnglish
Pages1-5
Number of pages5
JournalClinical Journal of Gastroenterology
DOIs
Publication statusAccepted/In press - Feb 15 2018

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Neuroendocrine Carcinoma
Endoscopy
Survival
Neuroendocrine Tumors
Neoplasms
Drug Therapy
Chromogranin A
Synaptophysin
Jejunum
Lymph Node Excision
Biopsy
Therapeutics

Keywords

  • Double balloon endosopy
  • Neuroendocrine carcinoma
  • Small intestine

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A case of small intestinal neuroendocrine carcinoma diagnosed using double-balloon endoscopy with long-term survival. / Kawano, Seiji; Miyashima, Yuichi; Miyabe, Yoshio; Kawai, Yoshinari; Murata, Toshihiro; Uda, Masashi; Inokuchi, Toshihiro; Okada, Hiroyuki.

In: Clinical Journal of Gastroenterology, 15.02.2018, p. 1-5.

Research output: Contribution to journalArticle

Kawano, Seiji ; Miyashima, Yuichi ; Miyabe, Yoshio ; Kawai, Yoshinari ; Murata, Toshihiro ; Uda, Masashi ; Inokuchi, Toshihiro ; Okada, Hiroyuki. / A case of small intestinal neuroendocrine carcinoma diagnosed using double-balloon endoscopy with long-term survival. In: Clinical Journal of Gastroenterology. 2018 ; pp. 1-5.
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