A case of refractory langerhans cell histiocytosis complicated with hemophagocytic lymphohistiocytosis rescued by cord blood transplantation with reduced-intensity conditioning

Kana Washio; Michiko Muraoka; Kiichiro Kanemitsu; Megumi Oda; Akira Shimada

A case of refractory langerhans cell histiocytosis complicated with hemophagocytic lymphohistiocytosis rescued by cord blood transplantation with reduced-intensity conditioning

Kana Washio, Michiko Muraoka, Kiichiro Kanemitsu, Megumi Oda, Akira Shimada

University Hospital

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.

Original language	English
Pages (from-to)	249-254
Number of pages	6
Journal	Acta medica Okayama
Volume	71
Issue number	3
Publication status	Published - 2017

Keywords

Hematopoietic stem cell transplantation (HSCT)
Hemophagocytic lymphohistiocytosis (HLH)
Langerhans cell histiocytosis (LCH)
Reduced-intensity conditioning (RIC)
Refractory

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "A case of refractory langerhans cell histiocytosis complicated with hemophagocytic lymphohistiocytosis rescued by cord blood transplantation with reduced-intensity conditioning",

abstract = "We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.",

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AU - Muraoka, Michiko

AU - Kanemitsu, Kiichiro

AU - Oda, Megumi

AU - Shimada, Akira

PY - 2017

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AB - We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.

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KW - Hemophagocytic lymphohistiocytosis (HLH)

KW - Langerhans cell histiocytosis (LCH)

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A case of refractory langerhans cell histiocytosis complicated with hemophagocytic lymphohistiocytosis rescued by cord blood transplantation with reduced-intensity conditioning

Abstract

Keywords

ASJC Scopus subject areas

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