A case of refractory langerhans cell histiocytosis complicated with hemophagocytic lymphohistiocytosis rescued by cord blood transplantation with reduced-intensity conditioning

Kana Washio, Michiko Muraoka, Kiichiro Kanamitsu, Megumi Oda, Akira Shimada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We diagnosed a female infant with Langerhans cell histiocytosis (LCH) who was refractory to conventional chemotherapy. She showed refractory inflammation that was complicated with hemophagocytic lymphohistiocytosis (HLH) during LCH chemotherapy; therefore, we changed the protocol to HLH2004 (dexamethasone, cyclosporine A and VP16). However, there were no signs of hematological recovery. We therefore performed cord blood transplantation with reduced-intensity conditioning, and she achieved complete remission for over 2 years. As salvage therapy for refractory LCH, hematopoietic stem cell transplantation may be a good therapeutic choice, especially when LCH is complicated with HLH.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalActa medica Okayama
Volume71
Issue number3
Publication statusPublished - 2017

Keywords

  • Hematopoietic stem cell transplantation (HSCT)
  • Hemophagocytic lymphohistiocytosis (HLH)
  • Langerhans cell histiocytosis (LCH)
  • Reduced-intensity conditioning (RIC)
  • Refractory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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