A Case of Primary Acinic Cell Carcinoma(ACC)of the Breast

Hiroshi Kawai, Ryoma Sugimoto, Norichika Iga, Hirokuni Ikeda, Ryosuke Yoshida, Naohisa Waki, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita

Research output: Contribution to journalArticle

Abstract

A49 -year-old woman presented with a 3.5 cm mass in her right breast. Mammography revealed a lobular mass with poorly defined margins and no microcalcification. Ultrasonography showed a hypoechoic mass with an irregular margin. The tumor was diagnosed as breast carcinoma using a core needle biopsy. The patient underwent a modified radical mastectomy with sentinel lymph node biopsy, and received adjuvant chemotherapy. The tumor consisted of 2 types of carcinoma. The center of the tumor was solid-tubular carcinoma, and the periphery was acinic cell carcinoma(ACC). Histopathologically, the neoplastic cells of the periphery were characterized by widespread acinic cell-like differentiation with a eosinophilic granular or clear cytoplasm, resembling acinic cells of the parotid gland(t3, f[+], ly0, v0, n0, stage II B). Immunohistochemically, the specimens tested positive for salivary gland amylase, and negative for collagen type IV , ER, PgR, and HER2. We administered UFT as adjuvant chemotherapy. Eight months after surgery, local recurrence was observed. ACC of the breast is rare, and has been reported to have a good prognosis. Further investigations are needed to elucidate its true histogenesis the appropriate treatment.

Original languageEnglish
Pages (from-to)2019-2021
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume43
Issue number12
Publication statusPublished - Nov 1 2016
Externally publishedYes

Fingerprint

Acinar Cell Carcinoma
Breast
Acinar Cells
Adjuvant Chemotherapy
Modified Radical Mastectomy
Large-Core Needle Biopsy
Calcinosis
Sentinel Lymph Node Biopsy
Neoplasms
Collagen Type IV
Parotid Gland
Mammography
Amylases
Salivary Glands
Cell Differentiation
Ultrasonography
Cytoplasm
Adenocarcinoma
Breast Neoplasms
Carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kawai, H., Sugimoto, R., Iga, N., Ikeda, H., Yoshida, R., Waki, N., ... Yamashita, K. (2016). A Case of Primary Acinic Cell Carcinoma(ACC)of the Breast. Gan to kagaku ryoho. Cancer & chemotherapy, 43(12), 2019-2021.

A Case of Primary Acinic Cell Carcinoma(ACC)of the Breast. / Kawai, Hiroshi; Sugimoto, Ryoma; Iga, Norichika; Ikeda, Hirokuni; Yoshida, Ryosuke; Waki, Naohisa; Ishizaki, Masahiro; Nishi, Hideyuki; Yamashita, Kazuki.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 43, No. 12, 01.11.2016, p. 2019-2021.

Research output: Contribution to journalArticle

Kawai, H, Sugimoto, R, Iga, N, Ikeda, H, Yoshida, R, Waki, N, Ishizaki, M, Nishi, H & Yamashita, K 2016, 'A Case of Primary Acinic Cell Carcinoma(ACC)of the Breast', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 43, no. 12, pp. 2019-2021.
Kawai H, Sugimoto R, Iga N, Ikeda H, Yoshida R, Waki N et al. A Case of Primary Acinic Cell Carcinoma(ACC)of the Breast. Gan to kagaku ryoho. Cancer & chemotherapy. 2016 Nov 1;43(12):2019-2021.
Kawai, Hiroshi ; Sugimoto, Ryoma ; Iga, Norichika ; Ikeda, Hirokuni ; Yoshida, Ryosuke ; Waki, Naohisa ; Ishizaki, Masahiro ; Nishi, Hideyuki ; Yamashita, Kazuki. / A Case of Primary Acinic Cell Carcinoma(ACC)of the Breast. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2016 ; Vol. 43, No. 12. pp. 2019-2021.
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