A case of pineal pure germinoma metastasized to the lumbosacral extradural space 8 years after initial therapy. Case report and review of literature

Yasuyuki Miyoshi, Masako Omori, Nobuyuki Kobayashi, Toshihiro Masuko, Eiju Watanabe, Isao Date

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An 11-year-old boy first presented with a pineal tumor identified by neuroimaging but without positive serum or cerebrospinal fluid markers. The tumor disappeared after the craniotomy and following cranial irradiation. The pathologic diagnosis of the tumor was of a pure germinoma. Eight years later he returned to the hospital with spinal epidural metastasis from the pineal germinoma and required surgery. Intraoperative findings showed that the spinal tumor was solitarily located in the epidural space. Pathologically the tumor was a pure germinoma metastasis. He was treated by a combination of whole spinal irradiation and chemotherapy. The tumor disappeared after the therapy. A pineal germinoma occasionally disseminates through the ventricular system and spinal subarachnoid region. However, a solitary spinal epidural metastasis from pineal germinoma has rarely been reported. Regarding the route of this metastasis, we speculate that the CSF dissemination of the germinoma cells occurred first and some of those cells were trapped in the spinal nerve sleeve and extended into the epidural space.

Original languageEnglish
Pages (from-to)745-752
Number of pages8
JournalNeurological Surgery
Volume34
Issue number7
Publication statusPublished - Jul 2006

Fingerprint

Germinoma
Neoplasm Metastasis
Epidural Space
Neoplasms
Therapeutics
Pinealoma
Cranial Irradiation
Spinal Nerves
Craniotomy
Neuroimaging
Cerebrospinal Fluid
Drug Therapy
Serum

Keywords

  • Pineal germinoma
  • Pure germinoma
  • Spinal extradural metastasis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

A case of pineal pure germinoma metastasized to the lumbosacral extradural space 8 years after initial therapy. Case report and review of literature. / Miyoshi, Yasuyuki; Omori, Masako; Kobayashi, Nobuyuki; Masuko, Toshihiro; Watanabe, Eiju; Date, Isao.

In: Neurological Surgery, Vol. 34, No. 7, 07.2006, p. 745-752.

Research output: Contribution to journalArticle

Miyoshi, Yasuyuki ; Omori, Masako ; Kobayashi, Nobuyuki ; Masuko, Toshihiro ; Watanabe, Eiju ; Date, Isao. / A case of pineal pure germinoma metastasized to the lumbosacral extradural space 8 years after initial therapy. Case report and review of literature. In: Neurological Surgery. 2006 ; Vol. 34, No. 7. pp. 745-752.
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