A case of photoleukomelanoderma due to hydrochlorothiazide contained in Preminent®

Yoshitaka Nakamura; Kei Nemoto; Emi Yokoyama; Masahiko Muto

doi:10.2336/nishinihonhifu.73.482

A case of photoleukomelanoderma due to hydrochlorothiazide contained in Preminent®

Yoshitaka Nakamura, Kei Nemoto, Emi Yokoyama, Masahiko Muto

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

A 75-year-old female had been treated with Nu-Lotan® (losartanpotassium) for hypertension. One month later, her treatment was changed from Nu-Lotan® to Preminent®(losartanpotassium/hydrochlorothiazide) and she developed pruritic edematous erythema on sun-exposed areas. Three month later eruptions appeared and pigmentations and depigmentations developed on the same areas. The minimal erythema dose (MED) of UVA was decreased to 4.4 J/cm². On withdrawal of the Preminent®, the MED was normalized. We made a diagnosis of photoleukomelanoderma due to hydrochlorothiazide contained in Preminent®.

Original language	English
Pages (from-to)	482-485
Number of pages	4
Journal	Nishinihon Journal of Dermatology
Volume	73
Issue number	5
DOIs	https://doi.org/10.2336/nishinihonhifu.73.482
Publication status	Published - Dec 1 2011
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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Nakamura, Y., Nemoto, K., Yokoyama, E., & Muto, M. (2011). A case of photoleukomelanoderma due to hydrochlorothiazide contained in Preminent®. Nishinihon Journal of Dermatology, 73(5), 482-485. https://doi.org/10.2336/nishinihonhifu.73.482

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title = "A case of photoleukomelanoderma due to hydrochlorothiazide contained in Preminent{\textregistered}",

abstract = "A 75-year-old female had been treated with Nu-Lotan{\textregistered} (losartanpotassium) for hypertension. One month later, her treatment was changed from Nu-Lotan{\textregistered} to Preminent{\textregistered}(losartanpotassium/hydrochlorothiazide) and she developed pruritic edematous erythema on sun-exposed areas. Three month later eruptions appeared and pigmentations and depigmentations developed on the same areas. The minimal erythema dose (MED) of UVA was decreased to 4.4 J/cm2. On withdrawal of the Preminent{\textregistered}, the MED was normalized. We made a diagnosis of photoleukomelanoderma due to hydrochlorothiazide contained in Preminent{\textregistered}.",

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