A Case of Nephrotic Syndrome and Renal Dysfunction in a Pregnant Woman with Diabetes Mellitus

K. Hironaka, H. Makino, I. Kumagai, T. Haramoto, Y. Yamasaki, K. Shikata, M. Takahashi, M. Nishii, Z. Ota

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A 29‐year‐old diabetic woman who developed severe anaemia, nephrotic syndrome, and hypertension before the 28th week of gestation, had residual evidence of toxaemia and renal dysfunction more than 1 month following delivery. The histopathological findings of renal biopsy specimens were considered most consistent with toxaemia of pregnancy complicated by diabetic glomerulosclerosis. We consider that rapid acceleration of renal dysfunction may have been induced by: (1) poor control of diabetes before pregnancy; (2) glomerular hyperfiltration of the remnant nephrons throughout pregnancy; (3) hypercoagulopathy associated with pregnancy; (4) appearance of hypertension following these three conditions. 1992 Diabetes UK

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalDiabetic Medicine
Issue number3
Publication statusPublished - Apr 1992



  • Diabetic glomerulosclerosis
  • Glomerular hyperfiltration
  • Hypercoagulopathy
  • Toxaemia of pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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