A case of minimal change nephrotic syndrome manifesting acute renal failure in the course of systemic lupus erythematosus

Taro Sugimoto, Yasushi Yamasaki, Mizuho Kobayashi, Hitomi Usui, Mitsuhiro Matsuda, Tetsuya Ohishi, Haruo Ichikawa, Yoshio Nakamura, Yoshio Nagake, Hirofumi Makino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A 51-year-old woman with systematic lupus erythematosus (SLE) associated with minimal change nephrotic syndrome(MCNS) is described. The patient was diagnosed as SLE at 33 years of age. After steroid therapy for two years, the patient's course was uneventful without therapy until June 2000, when facial erythema and facial, pretibial edema developed. On admission, proteinuria and renal dysfunction were detected. Subsequently, oliguric acute renal failure developed and hemodialysis was started. Laboratory examination showed no significant change in complements and and ds-DNA antibody levels. Renal biopsy revealed minor glomerular abnormalities without the deposition of immune complexes. Electron microscopic examination showed foot process fusion and a vacuolar change in glomerular epithelial cells. The diagnosis of MCNS was made and administration of steroid (40 mg/day) was started. Urine volume and renal function improved after 2 weeks, and nephrotic syndrome remitted completely after 5 weeks. Although the association of SLE and MCNS is rare, the findings suggest that in the course of SLE manifesting acute ranal failure, not only lupus nephritis, but also the complication of MCNS should be considered.

Original languageEnglish
Pages (from-to)476-482
Number of pages7
JournalJapanese Journal of Nephrology
Volume44
Issue number5
Publication statusPublished - 2002

Keywords

  • Acute renal failure
  • Minimal change nephrotic syndrome
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Nephrology

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