A case of miliary tuberculosis following transurethral surgery and prostate biopsy after intravesical Bacillus Calmette–Guerin immunotherapy

Yoshiaki Kurokawa, Taketo Kawai, Jimpei Miyakawa, Naohiro Makise, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Tetsuo Ushiku, Haruki Kume

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Introduction: Intravesical Bacillus Calmette–Guerin immunotherapy is known to prevent recurrence of bladder cancer, but it can cause tuberculosis infections as an adverse event. Case presentation: A 75-year-old man visited our hospital due to hematuria. The patient was diagnosed with bladder cancer and underwent transurethral resection of the bladder tumor. Postoperatively, the patient received Bacillus Calmette–Guerin immunotherapy. One year later, we performed transurethral surgery and prostate biopsy because of cystoscopic findings showing nodulous lesions in the bladder and an elevated serum prostate-specific antigen level. The patient presented with high fever and malaise since the surgery. After careful examination, the patient was diagnosed with miliary tuberculosis caused by Mycobacterium bovis. The pathology of the bladder and prostate revealed acid-fast bacilli collection by Ziehl–Neelsen staining. Conclusion: The surgery exacerbated the local infection into a systemic infection. The risk of developing miliary tuberculosis should be considered at transurethral surgery or prostate biopsy in patients after intravesical Bacillus Calmette–Guerin immunotherapy.

Original languageEnglish
JournalIJU Case Reports
DOIs
Publication statusAccepted/In press - 2021
Externally publishedYes

Keywords

  • BCG immunotherapy
  • bladder cancer
  • miliary tuberculosis
  • Mycobacterium bovis
  • systemic infection

ASJC Scopus subject areas

  • Urology

Fingerprint

Dive into the research topics of 'A case of miliary tuberculosis following transurethral surgery and prostate biopsy after intravesical Bacillus Calmette–Guerin immunotherapy'. Together they form a unique fingerprint.

Cite this