A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia

Seiko Mitsui, Yoshio Kawakami, Takashi Katayama, Masayuki Kishida, Masaaki Usui, Tomoko Hashimoto

Research output: Contribution to journalArticle

Abstract

A 77-year-old female with a 19-year history of rheumatoid arthritis was admitted to our hospital because of the simultaneous appearance of oral mucositis and erosions on her back accompanied by appetite loss.She had been treated with increasing doses of oral methotrexate (MTX), which had started 3 years and 9 months previously, up to 8 mg/week combined with oral prednisolone 5 mg/day.Laboratory investigation revealed leukocytopenia and thrombocytopenia, followed by anemia 3 days later.MTX was stopped and the patient was successfully treated with folic acid 24 mg/day and granulocytecolony stimulating factor 75 μg/day for 3 days.Although oral mucositis is a well-known side effect of MTX, the initial diagnosis of our case was difficult because of the unusual symptom of erosions on her back, which were reminiscent of pemphigus.It is important to recognize that oral mucositis is a predictive sign of bone marrow suppression and to be aware of the appearance of skin erosions and/or ulcerations as side effects of MTX therapy.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalNishinihon Journal of Dermatology
Volume78
Issue number4
Publication statusPublished - 2016

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Stomatitis
Pancytopenia
Methotrexate
Skin
Pemphigus
Leukopenia
Appetite
Prednisolone
Folic Acid
Thrombocytopenia
Anemia
Rheumatoid Arthritis
Bone Marrow
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Mitsui, S., Kawakami, Y., Katayama, T., Kishida, M., Usui, M., & Hashimoto, T. (2016). A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia. Nishinihon Journal of Dermatology, 78(4), 391-394.

A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia. / Mitsui, Seiko; Kawakami, Yoshio; Katayama, Takashi; Kishida, Masayuki; Usui, Masaaki; Hashimoto, Tomoko.

In: Nishinihon Journal of Dermatology, Vol. 78, No. 4, 2016, p. 391-394.

Research output: Contribution to journalArticle

Mitsui, S, Kawakami, Y, Katayama, T, Kishida, M, Usui, M & Hashimoto, T 2016, 'A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia', Nishinihon Journal of Dermatology, vol. 78, no. 4, pp. 391-394.
Mitsui S, Kawakami Y, Katayama T, Kishida M, Usui M, Hashimoto T. A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia. Nishinihon Journal of Dermatology. 2016;78(4):391-394.
Mitsui, Seiko ; Kawakami, Yoshio ; Katayama, Takashi ; Kishida, Masayuki ; Usui, Masaaki ; Hashimoto, Tomoko. / A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia. In: Nishinihon Journal of Dermatology. 2016 ; Vol. 78, No. 4. pp. 391-394.
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