TY - JOUR
T1 - A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia
AU - Mitsui, Seiko
AU - Kawakami, Yoshio
AU - Katayama, Takashi
AU - Kishida, Masayuki
AU - Usui, Masaaki
AU - Hashimoto, Tomoko
PY - 2016
Y1 - 2016
N2 - A 77-year-old female with a 19-year history of rheumatoid arthritis was admitted to our hospital because of the simultaneous appearance of oral mucositis and erosions on her back accompanied by appetite loss.She had been treated with increasing doses of oral methotrexate (MTX), which had started 3 years and 9 months previously, up to 8 mg/week combined with oral prednisolone 5 mg/day.Laboratory investigation revealed leukocytopenia and thrombocytopenia, followed by anemia 3 days later.MTX was stopped and the patient was successfully treated with folic acid 24 mg/day and granulocytecolony stimulating factor 75 μg/day for 3 days.Although oral mucositis is a well-known side effect of MTX, the initial diagnosis of our case was difficult because of the unusual symptom of erosions on her back, which were reminiscent of pemphigus.It is important to recognize that oral mucositis is a predictive sign of bone marrow suppression and to be aware of the appearance of skin erosions and/or ulcerations as side effects of MTX therapy.
AB - A 77-year-old female with a 19-year history of rheumatoid arthritis was admitted to our hospital because of the simultaneous appearance of oral mucositis and erosions on her back accompanied by appetite loss.She had been treated with increasing doses of oral methotrexate (MTX), which had started 3 years and 9 months previously, up to 8 mg/week combined with oral prednisolone 5 mg/day.Laboratory investigation revealed leukocytopenia and thrombocytopenia, followed by anemia 3 days later.MTX was stopped and the patient was successfully treated with folic acid 24 mg/day and granulocytecolony stimulating factor 75 μg/day for 3 days.Although oral mucositis is a well-known side effect of MTX, the initial diagnosis of our case was difficult because of the unusual symptom of erosions on her back, which were reminiscent of pemphigus.It is important to recognize that oral mucositis is a predictive sign of bone marrow suppression and to be aware of the appearance of skin erosions and/or ulcerations as side effects of MTX therapy.
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U2 - 10.2336/nishinihonhifu.78.391
DO - 10.2336/nishinihonhifu.78.391
M3 - Article
AN - SCOPUS:85006240218
VL - 78
SP - 391
EP - 394
JO - Nishinihon Journal of Dermatology
JF - Nishinihon Journal of Dermatology
SN - 0386-9784
IS - 4
ER -