A case of lymphomatoid gastropathy: An indolent CD56-positive atypical gastric lymphoid proliferation, mimicking aggressive NK/T cell lymphomas

Tsutomu Tanaka, Nirmeen Megahed, Katsuyoshi Takata, Naoko Asano, Yasumasa Niwa, Yoshiki Hirooka, Hidemi Goto

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Lymphomatoid gastropathy (LyGa) is a new evolving pathological entity that has been introduced recently. It is designated to describe CD56-positive atypical gastric lymphoid proliferation, mimicking NK/T cell lymphomas, that shows an indolent clinical course with spontaneous regression. We here present our experience with one new case diagnosed and treated in our hospital. An annual upper endoscopic check-up of a 50-year-old male with an unremarkable past history revealed a small reddish lesion on the posterior wall of the gastric angle. Endoscopic biopsy showed atypical cells of NK-cell lineage expressing CD56, CD16, CD3, perforin, and TIA-1, but not CD4, CD5, and CD8. Epstein-Barr virus encoded RNA was negative. The lesion regressed spontaneously after one month without treatment, but recurred two years later in a different site of the stomach with spontaneous regression again one month later. The recurrence of lymphomatoid gastropathy is very rare and should be diagnosed carefully to distinguish it from the aggressive lymphoma.

Original languageEnglish
Pages (from-to)786-789
Number of pages4
JournalPathology Research and Practice
Volume207
Issue number12
DOIs
Publication statusPublished - Dec 15 2011
Externally publishedYes

Keywords

  • Lymphoma
  • NK cells
  • Spontaneous regression
  • Stomach

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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