We present a 68-year-old man suffered from invasive fungal sphenoiditis. The patient complained of right eye pain and headache. His sphenoiditis was refractory to both medical management of VRCZ and sphenoidotomy, and finally he underwent sphenoid drill-out. After the final surgery, we performed therapeutic drug monitoring (TDM) and managed the internal use of VRCZ thoroughly. After a year, he has been doing well. When the clinical response is poor, or side effects are developed, measurement of the TDM is important as a tool of medical management.
|Number of pages||6|
|Journal||Otolaryngology - Head and Neck Surgery (Japan)|
|Publication status||Published - Aug 2014|
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