Abstract
Intravascular large B-cell lymphoma (IVL) is a rare systemic disease characterized by clonal proliferation of neoplastic lymphoid cells within the capillary lumina of small blood vessels. The most common sites of involvement are cerebrovascular or sinusoid areas, resulting in a wide variety of neurologic deficits. Herein we describe a case of IVL that presented with multiple internal and external organ involvements, including the skin, bilateral kidneys, and lung, and with an aggressive clinical course. The confirmative diagnosis was based on the microscopic findings of the skin lesion with a B-cell immunophenotype. The patient suffered from repeated severe dyspnea, hypoxemia, and high-grade fever with a simultaneous increase in serum lactate dehydrogenase and soluble IL-2 receptor levels. These manifestations responded dramatically to intravenous injection of corticosteroid (500 mg/day for 3 days). Despite various clinical presentations, no neurological abnormality was observed until the patient died 12 months after the initial combination chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 910-914 |
| Number of pages | 5 |
| Journal | Journal of Dermatology |
| Volume | 30 |
| Issue number | 12 |
| Publication status | Published - Dec 2003 |
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Keywords
- Combination chemotherapy
- Lactate dehydrogenase
- Lung involvement
- Multiple organ failure
- Neurological manifestations
ASJC Scopus subject areas
- Dermatology
Cite this
A Case of Intravascular Large B-Cell Lymphoma with Multiple Organ Involvement. / Yanagihori, Hirokatsu; Oyama, Noritaka; Kawakami, Yoshio; Sakuma-Oyama, Yohko; Nakamura, Koichiro; Iwatsuki, Keiji; Kaneko, Fumio.
In: Journal of Dermatology, Vol. 30, No. 12, 12.2003, p. 910-914.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Case of Intravascular Large B-Cell Lymphoma with Multiple Organ Involvement
AU - Yanagihori, Hirokatsu
AU - Oyama, Noritaka
AU - Kawakami, Yoshio
AU - Sakuma-Oyama, Yohko
AU - Nakamura, Koichiro
AU - Iwatsuki, Keiji
AU - Kaneko, Fumio
PY - 2003/12
Y1 - 2003/12
N2 - Intravascular large B-cell lymphoma (IVL) is a rare systemic disease characterized by clonal proliferation of neoplastic lymphoid cells within the capillary lumina of small blood vessels. The most common sites of involvement are cerebrovascular or sinusoid areas, resulting in a wide variety of neurologic deficits. Herein we describe a case of IVL that presented with multiple internal and external organ involvements, including the skin, bilateral kidneys, and lung, and with an aggressive clinical course. The confirmative diagnosis was based on the microscopic findings of the skin lesion with a B-cell immunophenotype. The patient suffered from repeated severe dyspnea, hypoxemia, and high-grade fever with a simultaneous increase in serum lactate dehydrogenase and soluble IL-2 receptor levels. These manifestations responded dramatically to intravenous injection of corticosteroid (500 mg/day for 3 days). Despite various clinical presentations, no neurological abnormality was observed until the patient died 12 months after the initial combination chemotherapy.
AB - Intravascular large B-cell lymphoma (IVL) is a rare systemic disease characterized by clonal proliferation of neoplastic lymphoid cells within the capillary lumina of small blood vessels. The most common sites of involvement are cerebrovascular or sinusoid areas, resulting in a wide variety of neurologic deficits. Herein we describe a case of IVL that presented with multiple internal and external organ involvements, including the skin, bilateral kidneys, and lung, and with an aggressive clinical course. The confirmative diagnosis was based on the microscopic findings of the skin lesion with a B-cell immunophenotype. The patient suffered from repeated severe dyspnea, hypoxemia, and high-grade fever with a simultaneous increase in serum lactate dehydrogenase and soluble IL-2 receptor levels. These manifestations responded dramatically to intravenous injection of corticosteroid (500 mg/day for 3 days). Despite various clinical presentations, no neurological abnormality was observed until the patient died 12 months after the initial combination chemotherapy.
KW - Combination chemotherapy
KW - Lactate dehydrogenase
KW - Lung involvement
KW - Multiple organ failure
KW - Neurological manifestations
UR - http://www.scopus.com/inward/record.url?scp=0942276891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0942276891&partnerID=8YFLogxK
M3 - Article
C2 - 14739519
AN - SCOPUS:0942276891
VL - 30
SP - 910
EP - 914
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 12
ER -