A case of intraoral plasmablastic lymphoma spontaneously regressed after biopsy in HIV-negative patient

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Abstract

Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that predominantly occurs in the oral cavity of individuals infected with human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV). However, it has been reported that it often occurs in HIV negative patients. In addition, although it is rare, there are cases where spontaneous withdrawal occurs without treatment. We describe a case of the PBL of oral mucosa type that occured in the mandibular gingival. The patient was a 69-year-old man who visited our hospital because of the growth of a gingival swelling in the right mandibular first molar buccal region. The swelling was identified as a spherical tumor with a smooth surface of about 10 mm in diameter. This was diagnosed clinically as a granulomatous epulis, and we performed resection biopsy to establish definite diagnosis. From the histopathological and immunohistological search of the biopsy specimen, the extract was diagnosed as PBL. The patient was HIV-negative; confirmed as a result of the blood test. Afterwards, the biopsy section followed a good healing process, and we are continuing regular follow-up observation, but we do not recognize recurrence.

Original languageEnglish
JournalJournal of Oral and Maxillofacial Surgery, Medicine, and Pathology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

HIV
Biopsy
Gingival Diseases
Cheek
Mouth Mucosa
Hematologic Tests
Human Herpesvirus 4
Non-Hodgkin's Lymphoma
Mouth
Observation
Recurrence
Growth
Plasmablastic Lymphoma
Neoplasms
Therapeutics

Keywords

  • Epstein-Barr virus
  • Human immunodeficiency virus
  • Oral cavity
  • Plasmablastic lymphoma
  • Spontaneous regression

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology

Cite this

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title = "A case of intraoral plasmablastic lymphoma spontaneously regressed after biopsy in HIV-negative patient",
abstract = "Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that predominantly occurs in the oral cavity of individuals infected with human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV). However, it has been reported that it often occurs in HIV negative patients. In addition, although it is rare, there are cases where spontaneous withdrawal occurs without treatment. We describe a case of the PBL of oral mucosa type that occured in the mandibular gingival. The patient was a 69-year-old man who visited our hospital because of the growth of a gingival swelling in the right mandibular first molar buccal region. The swelling was identified as a spherical tumor with a smooth surface of about 10 mm in diameter. This was diagnosed clinically as a granulomatous epulis, and we performed resection biopsy to establish definite diagnosis. From the histopathological and immunohistological search of the biopsy specimen, the extract was diagnosed as PBL. The patient was HIV-negative; confirmed as a result of the blood test. Afterwards, the biopsy section followed a good healing process, and we are continuing regular follow-up observation, but we do not recognize recurrence.",
keywords = "Epstein-Barr virus, Human immunodeficiency virus, Oral cavity, Plasmablastic lymphoma, Spontaneous regression",
author = "Kisho Ono and Tatsuo Okui and Soichiro Ibaragi and Hotaka Kawai and Kyoichi Obata and Mariko Fujita and Akira Sasaki",
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AU - Ono, Kisho

AU - Okui, Tatsuo

AU - Ibaragi, Soichiro

AU - Kawai, Hotaka

AU - Obata, Kyoichi

AU - Fujita, Mariko

AU - Sasaki, Akira

PY - 2019/1/1

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N2 - Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that predominantly occurs in the oral cavity of individuals infected with human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV). However, it has been reported that it often occurs in HIV negative patients. In addition, although it is rare, there are cases where spontaneous withdrawal occurs without treatment. We describe a case of the PBL of oral mucosa type that occured in the mandibular gingival. The patient was a 69-year-old man who visited our hospital because of the growth of a gingival swelling in the right mandibular first molar buccal region. The swelling was identified as a spherical tumor with a smooth surface of about 10 mm in diameter. This was diagnosed clinically as a granulomatous epulis, and we performed resection biopsy to establish definite diagnosis. From the histopathological and immunohistological search of the biopsy specimen, the extract was diagnosed as PBL. The patient was HIV-negative; confirmed as a result of the blood test. Afterwards, the biopsy section followed a good healing process, and we are continuing regular follow-up observation, but we do not recognize recurrence.

AB - Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that predominantly occurs in the oral cavity of individuals infected with human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV). However, it has been reported that it often occurs in HIV negative patients. In addition, although it is rare, there are cases where spontaneous withdrawal occurs without treatment. We describe a case of the PBL of oral mucosa type that occured in the mandibular gingival. The patient was a 69-year-old man who visited our hospital because of the growth of a gingival swelling in the right mandibular first molar buccal region. The swelling was identified as a spherical tumor with a smooth surface of about 10 mm in diameter. This was diagnosed clinically as a granulomatous epulis, and we performed resection biopsy to establish definite diagnosis. From the histopathological and immunohistological search of the biopsy specimen, the extract was diagnosed as PBL. The patient was HIV-negative; confirmed as a result of the blood test. Afterwards, the biopsy section followed a good healing process, and we are continuing regular follow-up observation, but we do not recognize recurrence.

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KW - Oral cavity

KW - Plasmablastic lymphoma

KW - Spontaneous regression

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