A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis

Ryoto Hourai; Masatoshi Miyamura; Ryunosuke Tasaki; Akiko Iwata; Yoshihiro Takeda; Hideaki Morita; Nobuharu Hanaoka; Jun Tanigawa; Kensaku Shibata; Atsushi Takeshita; Mitsuhiro Kawano; Yasuharu Sato; Yoshinobu Hirose; Nobukazu Ishizaka

doi:10.1007/s00380-016-0794-1

A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis

Ryoto Hourai, Masatoshi Miyamura, Ryunosuke Tasaki, Akiko Iwata, Yoshihiro Takeda, Hideaki Morita, Nobuharu Hanaoka, Jun Tanigawa, Kensaku Shibata, Atsushi Takeshita, Mitsuhiro Kawano, Yasuharu Sato, Yoshinobu Hirose, Nobukazu Ishizaka

Research output: Contribution to journal › Article › peer-review

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Abstract

Immunoglobulin G4 (IgG4)-related disease is an emerging new clinicopathological disorder that is characterized by elevation of serum IgG4 levels and histological findings of IgG4-positive plasmacytic infiltration. IgG4-related disease may appear synchronously or metachronously in a wide variety of organs. The current patient was found to have pericardial effusion and retroperitoneal fibrosis. He was subsequently diagnosed with coronary artery stenosis. ¹⁸F-FDG positron emission tomography showed enhanced FDG uptake in lymph nodes as well as pericardial and peri-aortic tissue. Histopathology of the mediastinal lymph node showed the infiltration of numerous IgG4-positive cells, leading to the diagnosis of IgG4-related lymphadenopathy with pericardial and periarterial involvement.

Original language	English
Pages (from-to)	1709-1713
Number of pages	5
Journal	Heart and Vessels
Volume	31
Issue number	10
DOIs	https://doi.org/10.1007/s00380-016-0794-1
Publication status	Published - Oct 1 2016

Keywords

Cardiovascular system
IgG4-related disease
Lymphadenopathy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s00380-016-0794-1

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Hourai, R., Miyamura, M., Tasaki, R., Iwata, A., Takeda, Y., Morita, H., Hanaoka, N., Tanigawa, J., Shibata, K., Takeshita, A., Kawano, M., Sato, Y., Hirose, Y., & Ishizaka, N. (2016). A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis. Heart and Vessels, 31(10), 1709-1713. https://doi.org/10.1007/s00380-016-0794-1

A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis. / Hourai, Ryoto; Miyamura, Masatoshi; Tasaki, Ryunosuke; Iwata, Akiko; Takeda, Yoshihiro; Morita, Hideaki; Hanaoka, Nobuharu; Tanigawa, Jun; Shibata, Kensaku; Takeshita, Atsushi; Kawano, Mitsuhiro; Sato, Yasuharu; Hirose, Yoshinobu; Ishizaka, Nobukazu.

In: Heart and Vessels, Vol. 31, No. 10, 01.10.2016, p. 1709-1713.

Research output: Contribution to journal › Article › peer-review

Hourai, Ryoto ; Miyamura, Masatoshi ; Tasaki, Ryunosuke ; Iwata, Akiko ; Takeda, Yoshihiro ; Morita, Hideaki ; Hanaoka, Nobuharu ; Tanigawa, Jun ; Shibata, Kensaku ; Takeshita, Atsushi ; Kawano, Mitsuhiro ; Sato, Yasuharu ; Hirose, Yoshinobu ; Ishizaka, Nobukazu. / A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis. In: Heart and Vessels. 2016 ; Vol. 31, No. 10. pp. 1709-1713.

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AU - Morita, Hideaki

AU - Hanaoka, Nobuharu

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AU - Sato, Yasuharu

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AB - Immunoglobulin G4 (IgG4)-related disease is an emerging new clinicopathological disorder that is characterized by elevation of serum IgG4 levels and histological findings of IgG4-positive plasmacytic infiltration. IgG4-related disease may appear synchronously or metachronously in a wide variety of organs. The current patient was found to have pericardial effusion and retroperitoneal fibrosis. He was subsequently diagnosed with coronary artery stenosis. 18F-FDG positron emission tomography showed enhanced FDG uptake in lymph nodes as well as pericardial and peri-aortic tissue. Histopathology of the mediastinal lymph node showed the infiltration of numerous IgG4-positive cells, leading to the diagnosis of IgG4-related lymphadenopathy with pericardial and periarterial involvement.

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A case of IgG4-related lymphadenopathy, pericarditis, coronary artery periarteritis and luminal stenosis

Abstract

Keywords

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