A case of idiopathic deep vein thrombosis improved with glucocorticoid therapy

Research output: Contribution to journalArticle

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Abstract

A health, middle-aged Japanese man with no family history of thrombotic disorders presented with acute abdominal pain due to ischemic colitis. Two months later, he developed left leg pain and swelling. A venogram of the lower limbs, computed tomography, and a scintigram of pulmonary blood flow revealed deep vein thrombosis of the left lower limb extending to the inferior vena cava and emboli of both pulmonary arteries with bilateral pleural effusions. The responsible coagulation disorder was not detected in this case. Since these thrombi were refractory to the thrombolytic therapy was urokinase and anticoagulant therapy with warfarin, prednisolone was chosen for the suppression of accompanying thrombophlebitis. Two months following the initiation of prednisolone (20 mg/day), the venous thrombosis, abnormal pulmonary shadows, and pleural effusions had completely resolved. This case demonstrates the successful treatment of idiopathic venous and pulmonary thrombosis with glucocorticoids.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalHaematologia
Volume29
Issue number4
Publication statusPublished - 1999

Fingerprint

Venous Thrombosis
Glucocorticoids
Pleural Effusion
Prednisolone
Lung
Lower Extremity
Ischemic Colitis
Thrombophlebitis
Thrombolytic Therapy
Urokinase-Type Plasminogen Activator
Acute Pain
Inferior Vena Cava
Warfarin
Embolism
Anticoagulants
Abdominal Pain
Pulmonary Artery
Leg
Thrombosis
Therapeutics

Keywords

  • Activated protein C (APC) resistance
  • Deep vein thrombosis
  • Ischemic colitis
  • Pulmonary thrombosis
  • Vasculitis

ASJC Scopus subject areas

  • Hematology

Cite this

A case of idiopathic deep vein thrombosis improved with glucocorticoid therapy. / Otsuka, Fumio; Amano, T.; Uchida, Haruhito Adam; Ogura, T.; Makino, Hirofumi.

In: Haematologia, Vol. 29, No. 4, 1999, p. 305-312.

Research output: Contribution to journalArticle

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