A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA 1c

Hisakazu Nishimori, Keiko Harano, Hideho Wada, Satoshi Takano, Shinji Fukuda, Yukihito Takehara, Hiroshi Matsumoto, Isao Kumagai, Mitsune Tanimoto, Sho Takeda

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1 Citation (Scopus)

Abstract

Hemoglobin (Hb) Hiroshima is an Hb variant that travels rapidly on electrophoresis and shows a fourfold increase in oxygen affinity and a decreased Bohr effect. We encountered a 40-year-old male patient with erythremia and an undetectable HbA 1c level. The presence of an abnormal hemoglobin molecule was suggested by the results of high-performance liquid chromatography analysis. Subsequent gene analysis by direct sequencing confirmed Hb Hiroshima (β146 histidine → aspartic acid). Caution should be exercised when diagnosing erythremia.

Original languageEnglish
Pages (from-to)697-701
Number of pages5
JournalInternational journal of hematology
Volume95
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Abnormal hemoglobin
  • Erythropoietin
  • HbA
  • Hemoglobin Hiroshima
  • Hemoglobin variant

ASJC Scopus subject areas

  • Hematology

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    Nishimori, H., Harano, K., Wada, H., Takano, S., Fukuda, S., Takehara, Y., Matsumoto, H., Kumagai, I., Tanimoto, M., & Takeda, S. (2012). A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA 1c International journal of hematology, 95(6), 697-701. https://doi.org/10.1007/s12185-012-1066-1