TY - JOUR
T1 - A case of gastric cancer with rhabdoid features showing better prognosis through S-1/CDDP chemotherapy
AU - Mori, Yoshiko
AU - Kobayashi, Masahiko
AU - Ishihara, Shinichi
AU - Mizobuchi, Kouichi
AU - Kishi, Miki
AU - Kurosaki, Takeshi
AU - Miyake, Soichiro
AU - Watanabe, Nobuyuki
AU - Kimura, Keigo
AU - Kokudo, Yasutaka
AU - Muraoka, Atsushi
AU - Tatemoto, Akihiko
AU - Nagasaka, Takeshi
AU - Tsumura, Makoto
PY - 2012/5
Y1 - 2012/5
N2 - Although gastric cancers (GCs) with rhabdoid features are rare, they are known to show a poorer prognosis compared with conventional GCs. Indeed, more than half of reported GCs with rhabdoid features died within 6 months after receiving any kind of initial treatment. Obviously, no effective chemotherapy has been reported. In this study, we present a case of GC with rhabdoid features which showed a better response to a chemotherapy, S-1/CDDP, and lived for over 12 months after the initial chemotherapy. A 75-year-old man was seen in our hospital for epigastralgia. Detailed examinations revealed that he had GC at Stage IV. Consequently, he underwent S-1/CDDP treatment. This treatment produced a good response for 6 months, minimizing the size of the primary tumor and eradicating distant metastases. Re-growth of the primary tumor without uprising distant metastasis was confirmed 8 months after the initial S-1/CDDP treatment, and the patient went through a gastrectomy for curative care. After surgery, a precise pathological examination revealed that the primary tumor possessed a poorly differentiated adenocarcinoma that contained tumor cells with typical rhabdoid features. In the end, the patient died of liver metastasis 13 months after the initial S-1/CDDP chemotherapy.
AB - Although gastric cancers (GCs) with rhabdoid features are rare, they are known to show a poorer prognosis compared with conventional GCs. Indeed, more than half of reported GCs with rhabdoid features died within 6 months after receiving any kind of initial treatment. Obviously, no effective chemotherapy has been reported. In this study, we present a case of GC with rhabdoid features which showed a better response to a chemotherapy, S-1/CDDP, and lived for over 12 months after the initial chemotherapy. A 75-year-old man was seen in our hospital for epigastralgia. Detailed examinations revealed that he had GC at Stage IV. Consequently, he underwent S-1/CDDP treatment. This treatment produced a good response for 6 months, minimizing the size of the primary tumor and eradicating distant metastases. Re-growth of the primary tumor without uprising distant metastasis was confirmed 8 months after the initial S-1/CDDP treatment, and the patient went through a gastrectomy for curative care. After surgery, a precise pathological examination revealed that the primary tumor possessed a poorly differentiated adenocarcinoma that contained tumor cells with typical rhabdoid features. In the end, the patient died of liver metastasis 13 months after the initial S-1/CDDP chemotherapy.
KW - Cisplatin
KW - Malignant rhabdoid tumor of stomach
KW - S-1
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UR - http://www.scopus.com/inward/citedby.url?scp=84864003766&partnerID=8YFLogxK
M3 - Article
C2 - 22584342
AN - SCOPUS:84864003766
VL - 39
SP - 829
EP - 832
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 5
ER -
