A case of gastric cancer developed after pylorus-preserving gastrectomy in a patient with lynch syndrome

Nobuhiko Kanaya, Kohji Tanakaya, Kunitoshi Shigeyasu, Tomoyoshi Kunitomo, Rie Yamasaki, Hideki Aoki, Hitoshi Takeuchi

Research output: Contribution to journalArticle

Abstract

Lynch syndrome is an inherited autosomal dominant disorder caused by germ-line mutation of mismatch repair genes, in which a malignant tumor develops at a young age in the colon, endometrium, stomach, or other tissues. A 54-year-old patient with gastric cancer received pylorus-preserving gastrectomy, and a genetic examination confirmed a pathological variation of the MLH1 gene. Five years after surgery, an upper gastrointestinal endoscopy revealed a residual. 0-IIa + IIc gastric tumor approximately 2 cm in size extending from the anastomotic site to the lesser curvature side of the stomach. The remaining stomach was completely removed. The final diagnosis was T1b (SM) N1M0, Stage IB gastric cancer. Microsatellite instability was positive, and we attributed the cancer to Lynch syndrome. In Lynch syndrome, the risk of multicentric gastric cancer is higher than normal, and for the initial therapy, preventive total gastrectomy should be considered as an option.

Original languageEnglish
Pages (from-to)2264-2265
Number of pages2
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number12
Publication statusPublished - Nov 2014
Externally publishedYes

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Keywords

  • Gastric cancer
  • Lynch syndrome
  • Pylorus-preserving gastrectomy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kanaya, N., Tanakaya, K., Shigeyasu, K., Kunitomo, T., Yamasaki, R., Aoki, H., & Takeuchi, H. (2014). A case of gastric cancer developed after pylorus-preserving gastrectomy in a patient with lynch syndrome. Japanese Journal of Cancer and Chemotherapy, 41(12), 2264-2265.