A case of falciparum malaria successfully treated with intravenous artesunate

C. Yasuoka, A. Yasuoka, Y. Yamamoto, I. Genka, Toshimitsu Hatabu, S. Kohno, S. Oka, S. Kano

Research output: Contribution to journalArticle

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Abstract

The case was a 47-year-old Nigerian male who was thought to have contracted malaria in Nigeria and then manifested fever with chill, arthralgia and diarrhea in Japan. The blood test at International Medical Center of Japan revealed thrombocytopenia and anemia. Ring forms of 0.03% of his RBCs and ICT Malaria P.f/P.v test was also positive for Plasmodium falciparum. We prescribed mefloquine to him, but the number of the paresites in his peripheral blood did not decrease, and, in fact, they came to increase (maximum 6.66%) 20 hours after the drug treatment. As clinical condition of malaria were liable to change seriously, intravenous Artesunate (a qinghaosu derivative) was decided to be given additionally to the patient. Consequently the parasites disappeared in 20 hours from his blood but a low grade fever still continued possibly because of cholecystitis. At the same time of Artesunate treatment, hemoglobinuria started and anemia worsened partly because of his G-6-PD deficiency. All pending problems were improved by the time he left Japan and those parasites were finally found to be susceptible for mefloquine by the in vitro susceptibility test. This is the first reported case of falciparum malaria successfully treated with intravenous Artesunate in Japan.

Original languageEnglish
Pages (from-to)822-825
Number of pages4
JournalKansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume75
Issue number9
Publication statusPublished - 2001
Externally publishedYes

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Falciparum Malaria
Japan
Malaria
Mefloquine
His-His-His-His-His-His
Anemia
Parasites
Fever
Hemoglobinuria
Chills
Cholecystitis
Arthralgia
Hematologic Tests
Plasmodium falciparum
Nigeria
Thrombocytopenia
Diarrhea
artesunate
Therapeutics
Pharmaceutical Preparations

Cite this

A case of falciparum malaria successfully treated with intravenous artesunate. / Yasuoka, C.; Yasuoka, A.; Yamamoto, Y.; Genka, I.; Hatabu, Toshimitsu; Kohno, S.; Oka, S.; Kano, S.

In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 75, No. 9, 2001, p. 822-825.

Research output: Contribution to journalArticle

Yasuoka, C. ; Yasuoka, A. ; Yamamoto, Y. ; Genka, I. ; Hatabu, Toshimitsu ; Kohno, S. ; Oka, S. ; Kano, S. / A case of falciparum malaria successfully treated with intravenous artesunate. In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 2001 ; Vol. 75, No. 9. pp. 822-825.
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