Abstract
The case was a 47-year-old Nigerian male who was thought to have contracted malaria in Nigeria and then manifested fever with chill, arthralgia and diarrhea in Japan. The blood test at International Medical Center of Japan revealed thrombocytopenia and anemia. Ring forms of 0.03% of his RBCs and ICT Malaria P.f/P.v test was also positive for Plasmodium falciparum. We prescribed mefloquine to him, but the number of the paresites in his peripheral blood did not decrease, and, in fact, they came to increase (maximum 6.66%) 20 hours after the drug treatment. As clinical condition of malaria were liable to change seriously, intravenous Artesunate (a qinghaosu derivative) was decided to be given additionally to the patient. Consequently the parasites disappeared in 20 hours from his blood but a low grade fever still continued possibly because of cholecystitis. At the same time of Artesunate treatment, hemoglobinuria started and anemia worsened partly because of his G-6-PD deficiency. All pending problems were improved by the time he left Japan and those parasites were finally found to be susceptible for mefloquine by the in vitro susceptibility test. This is the first reported case of falciparum malaria successfully treated with intravenous Artesunate in Japan.
| Original language | English |
|---|---|
| Pages (from-to) | 822-825 |
| Number of pages | 4 |
| Journal | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases |
| Volume | 75 |
| Issue number | 9 |
| Publication status | Published - 2001 |
| Externally published | Yes |
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A case of falciparum malaria successfully treated with intravenous artesunate. / Yasuoka, C.; Yasuoka, A.; Yamamoto, Y.; Genka, I.; Hatabu, Toshimitsu; Kohno, S.; Oka, S.; Kano, S.
In: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 75, No. 9, 2001, p. 822-825.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of falciparum malaria successfully treated with intravenous artesunate
AU - Yasuoka, C.
AU - Yasuoka, A.
AU - Yamamoto, Y.
AU - Genka, I.
AU - Hatabu, Toshimitsu
AU - Kohno, S.
AU - Oka, S.
AU - Kano, S.
PY - 2001
Y1 - 2001
N2 - The case was a 47-year-old Nigerian male who was thought to have contracted malaria in Nigeria and then manifested fever with chill, arthralgia and diarrhea in Japan. The blood test at International Medical Center of Japan revealed thrombocytopenia and anemia. Ring forms of 0.03% of his RBCs and ICT Malaria P.f/P.v test was also positive for Plasmodium falciparum. We prescribed mefloquine to him, but the number of the paresites in his peripheral blood did not decrease, and, in fact, they came to increase (maximum 6.66%) 20 hours after the drug treatment. As clinical condition of malaria were liable to change seriously, intravenous Artesunate (a qinghaosu derivative) was decided to be given additionally to the patient. Consequently the parasites disappeared in 20 hours from his blood but a low grade fever still continued possibly because of cholecystitis. At the same time of Artesunate treatment, hemoglobinuria started and anemia worsened partly because of his G-6-PD deficiency. All pending problems were improved by the time he left Japan and those parasites were finally found to be susceptible for mefloquine by the in vitro susceptibility test. This is the first reported case of falciparum malaria successfully treated with intravenous Artesunate in Japan.
AB - The case was a 47-year-old Nigerian male who was thought to have contracted malaria in Nigeria and then manifested fever with chill, arthralgia and diarrhea in Japan. The blood test at International Medical Center of Japan revealed thrombocytopenia and anemia. Ring forms of 0.03% of his RBCs and ICT Malaria P.f/P.v test was also positive for Plasmodium falciparum. We prescribed mefloquine to him, but the number of the paresites in his peripheral blood did not decrease, and, in fact, they came to increase (maximum 6.66%) 20 hours after the drug treatment. As clinical condition of malaria were liable to change seriously, intravenous Artesunate (a qinghaosu derivative) was decided to be given additionally to the patient. Consequently the parasites disappeared in 20 hours from his blood but a low grade fever still continued possibly because of cholecystitis. At the same time of Artesunate treatment, hemoglobinuria started and anemia worsened partly because of his G-6-PD deficiency. All pending problems were improved by the time he left Japan and those parasites were finally found to be susceptible for mefloquine by the in vitro susceptibility test. This is the first reported case of falciparum malaria successfully treated with intravenous Artesunate in Japan.
UR - http://www.scopus.com/inward/record.url?scp=0035459312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035459312&partnerID=8YFLogxK
M3 - Article
C2 - 11605194
AN - SCOPUS:0035459312
VL - 75
SP - 822
EP - 825
JO - Nippon Densenbyo Gakkai zasshi
JF - Nippon Densenbyo Gakkai zasshi
SN - 0387-5911
IS - 9
ER -