Abstract
Background: Brunsting-Perry pemphigoid is a rare subepidermal blistering disease characterized by scarring blisters on the head and neck. However, the identity of the responsible autoantigens is still unresolved. Methods: We reported a patient with epidermolysis bullosa acquisita who had clinical features typical of Brunsting-Perry pemphigoid and investigated the involved type VII collagen epitopes. The patient was a 65-year-old Japanese woman with a 20-month history of recurrent subepidermal bullae on her head, face, and neck. Results: Immunoblot studies revealed that the serum of this patient reacted with type VII collagen, specifically with the noncollagenous domain 1 and the triple-helical domain. The patient responded completely to colchicine monotherapy. Limitations: This study was performed on only one case. Conclusion: This study suggests that Brunsting-Perry pemphigoid may be a clinical variant of epidermolysis bullosa acquisita.
| Original language | English |
|---|---|
| Pages (from-to) | 715-719 |
| Number of pages | 5 |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 61 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 2009 |
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Keywords
- Brunsting-Perry pemphigoid
- epidermolysis bullosa acquisita
- type VII collagen
ASJC Scopus subject areas
- Dermatology
Cite this
A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine. / Tanaka, Noriko; Dainichi, Teruki; Ohyama, Bungo; Yasumoto, Shinichiro; Oono, Takashi; Iwatsuki, Keiji; Elfert, Susanne; Fritsch, Anja; Bruckner-Tuderman, Leena; Hashimoto, Takashi.
In: Journal of the American Academy of Dermatology, Vol. 61, No. 4, 10.2009, p. 715-719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine
AU - Tanaka, Noriko
AU - Dainichi, Teruki
AU - Ohyama, Bungo
AU - Yasumoto, Shinichiro
AU - Oono, Takashi
AU - Iwatsuki, Keiji
AU - Elfert, Susanne
AU - Fritsch, Anja
AU - Bruckner-Tuderman, Leena
AU - Hashimoto, Takashi
PY - 2009/10
Y1 - 2009/10
N2 - Background: Brunsting-Perry pemphigoid is a rare subepidermal blistering disease characterized by scarring blisters on the head and neck. However, the identity of the responsible autoantigens is still unresolved. Methods: We reported a patient with epidermolysis bullosa acquisita who had clinical features typical of Brunsting-Perry pemphigoid and investigated the involved type VII collagen epitopes. The patient was a 65-year-old Japanese woman with a 20-month history of recurrent subepidermal bullae on her head, face, and neck. Results: Immunoblot studies revealed that the serum of this patient reacted with type VII collagen, specifically with the noncollagenous domain 1 and the triple-helical domain. The patient responded completely to colchicine monotherapy. Limitations: This study was performed on only one case. Conclusion: This study suggests that Brunsting-Perry pemphigoid may be a clinical variant of epidermolysis bullosa acquisita.
AB - Background: Brunsting-Perry pemphigoid is a rare subepidermal blistering disease characterized by scarring blisters on the head and neck. However, the identity of the responsible autoantigens is still unresolved. Methods: We reported a patient with epidermolysis bullosa acquisita who had clinical features typical of Brunsting-Perry pemphigoid and investigated the involved type VII collagen epitopes. The patient was a 65-year-old Japanese woman with a 20-month history of recurrent subepidermal bullae on her head, face, and neck. Results: Immunoblot studies revealed that the serum of this patient reacted with type VII collagen, specifically with the noncollagenous domain 1 and the triple-helical domain. The patient responded completely to colchicine monotherapy. Limitations: This study was performed on only one case. Conclusion: This study suggests that Brunsting-Perry pemphigoid may be a clinical variant of epidermolysis bullosa acquisita.
KW - Brunsting-Perry pemphigoid
KW - epidermolysis bullosa acquisita
KW - type VII collagen
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UR - http://www.scopus.com/inward/citedby.url?scp=69949173611&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2008.12.020
DO - 10.1016/j.jaad.2008.12.020
M3 - Article
VL - 61
SP - 715
EP - 719
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 4
ER -