A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine

Noriko Tanaka, Teruki Dainichi, Bungo Ohyama, Shinichiro Yasumoto, Takashi Oono, Keiji Iwatsuki, Susanne Elfert, Anja Fritsch, Leena Bruckner-Tuderman, Takashi Hashimoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Brunsting-Perry pemphigoid is a rare subepidermal blistering disease characterized by scarring blisters on the head and neck. However, the identity of the responsible autoantigens is still unresolved. Methods: We reported a patient with epidermolysis bullosa acquisita who had clinical features typical of Brunsting-Perry pemphigoid and investigated the involved type VII collagen epitopes. The patient was a 65-year-old Japanese woman with a 20-month history of recurrent subepidermal bullae on her head, face, and neck. Results: Immunoblot studies revealed that the serum of this patient reacted with type VII collagen, specifically with the noncollagenous domain 1 and the triple-helical domain. The patient responded completely to colchicine monotherapy. Limitations: This study was performed on only one case. Conclusion: This study suggests that Brunsting-Perry pemphigoid may be a clinical variant of epidermolysis bullosa acquisita.

Original languageEnglish
Pages (from-to)715-719
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume61
Issue number4
DOIs
Publication statusPublished - Oct 2009

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Epidermolysis Bullosa Acquisita
Bullous Pemphigoid
Colchicine
Collagen Type VII
Blister
Neck
Head
Autoantigens
Cicatrix
Epitopes
Serum

Keywords

  • Brunsting-Perry pemphigoid
  • epidermolysis bullosa acquisita
  • type VII collagen

ASJC Scopus subject areas

  • Dermatology

Cite this

A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine. / Tanaka, Noriko; Dainichi, Teruki; Ohyama, Bungo; Yasumoto, Shinichiro; Oono, Takashi; Iwatsuki, Keiji; Elfert, Susanne; Fritsch, Anja; Bruckner-Tuderman, Leena; Hashimoto, Takashi.

In: Journal of the American Academy of Dermatology, Vol. 61, No. 4, 10.2009, p. 715-719.

Research output: Contribution to journalArticle

Tanaka, N, Dainichi, T, Ohyama, B, Yasumoto, S, Oono, T, Iwatsuki, K, Elfert, S, Fritsch, A, Bruckner-Tuderman, L & Hashimoto, T 2009, 'A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine', Journal of the American Academy of Dermatology, vol. 61, no. 4, pp. 715-719. https://doi.org/10.1016/j.jaad.2008.12.020
Tanaka, Noriko ; Dainichi, Teruki ; Ohyama, Bungo ; Yasumoto, Shinichiro ; Oono, Takashi ; Iwatsuki, Keiji ; Elfert, Susanne ; Fritsch, Anja ; Bruckner-Tuderman, Leena ; Hashimoto, Takashi. / A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine. In: Journal of the American Academy of Dermatology. 2009 ; Vol. 61, No. 4. pp. 715-719.
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