A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine

Noriko Tanaka, Teruki Dainichi, Bungo Ohyama, Shinichiro Yasumoto, Takashi Oono, Keiji Iwatsuki, Susanne Elfert, Anja Fritsch, Leena Bruckner-Tuderman, Takashi Hashimoto

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Brunsting-Perry pemphigoid is a rare subepidermal blistering disease characterized by scarring blisters on the head and neck. However, the identity of the responsible autoantigens is still unresolved. Methods: We reported a patient with epidermolysis bullosa acquisita who had clinical features typical of Brunsting-Perry pemphigoid and investigated the involved type VII collagen epitopes. The patient was a 65-year-old Japanese woman with a 20-month history of recurrent subepidermal bullae on her head, face, and neck. Results: Immunoblot studies revealed that the serum of this patient reacted with type VII collagen, specifically with the noncollagenous domain 1 and the triple-helical domain. The patient responded completely to colchicine monotherapy. Limitations: This study was performed on only one case. Conclusion: This study suggests that Brunsting-Perry pemphigoid may be a clinical variant of epidermolysis bullosa acquisita.

Original languageEnglish
Pages (from-to)715-719
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume61
Issue number4
DOIs
Publication statusPublished - Oct 1 2009

Keywords

  • Brunsting-Perry pemphigoid
  • epidermolysis bullosa acquisita
  • type VII collagen

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine'. Together they form a unique fingerprint.

  • Cite this

    Tanaka, N., Dainichi, T., Ohyama, B., Yasumoto, S., Oono, T., Iwatsuki, K., Elfert, S., Fritsch, A., Bruckner-Tuderman, L., & Hashimoto, T. (2009). A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine. Journal of the American Academy of Dermatology, 61(4), 715-719. https://doi.org/10.1016/j.jaad.2008.12.020