A case of enterochromaffin-like cell neuroendocrine tumor associated with parietal cell dysfunction which was successfully treated with somatostatin analogue

Ryosuke Hirai, Ken Haruma, Hiroyuki Okada, Junya Itakura, Motowo Mizuno

Research output: Contribution to journalArticlepeer-review

Abstract

We report here a case of a 62-year-old woman with multiple gastric enterochromaffin-like cell neuroendocrine tumor caused by hypergastrinemia due to parietal cell dysfunction that was successfully treated with somatostatin analogue. Esophagogastroduodenoscopy revealed several G1 neuroendocrine tumors, 10 mm in diameter, in the body of the stomach. No evidence of autoimmune gastritis, Helicobacter pylori infection, neuroendocrine neoplasia type 1, or Zollinger–Ellison syndrome was identified. The pattern of immunohistochemical staining of the background gastric mucosa was suggestive of parietal cell dysfunction. She was treated with long-acting release octreotide acetate. Complete response was confirmed after 9 months and was maintained for 22 months.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalClinical Journal of Gastroenterology
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2022

Keywords

  • Enterochromaffin-like cell neuroendocrine tumor
  • Hypergastrinemia
  • Parietal cell dysfunction
  • Somatostatin analogue

ASJC Scopus subject areas

  • Gastroenterology

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