A case of elderly-onset type 1 diabetes with first-degree family history with negative GAD antibody and positive IA-2 antibody

Michiko Asano, Atsuhito Tone, Akihiro Katayama, Mahoko Furujo, Chigusa Higuchi, Keiko Tsukamoto, Izumi Iseda, Kazuyuki Hida, Tokurou Uesu, Kenichi Shikata

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A 50-year-old man, whose second of two daughters was treated for type 1 diabetes, seen for polyuria and weight loss in August 2008 had been found to have HbA1C of 6.2% in an annual physical cheakup in April 2008. He was hospitalized for markedly elevated HbA1C of 10.3% and plasma glucose of 463 mg/d/ detected in a blood test Laboratory studies showed a urinary CPR concentration of 21.9 μg/day and serum CPR of 0.2 ng/m/ before and 0.4 ng/m/ 6 minutes after glucagon administration, indicating decreased insulin secretion. Intensive insulin therapy was initiated. Although GAD antibody was negative, IA-2 antibody was positive (9.1 U/ml), leading to a diagnosis of type 1 diabetes mellitus. HLA typing was DRB1* 010101 and 090102, type 1 diabetes-susceptibility gene, identical to the typing of his second daughter. This case of elderly-onset of type 1 diabetes is interesting, manifesting negative GAD antibody and positive IA-2 antibody, especially with a family history of type 1 diabetes.

Original languageEnglish
Pages (from-to)174-179
Number of pages6
JournalJournal of the Japan Diabetes Society
Issue number3
Publication statusPublished - Mar 2010


ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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