A case of diffuse panbronchiolitis, associated with severe pulmonary hypertension, managed with bilateral lung transplantation from a brain-dead donor

Yasutaka Onishi, Tetsuji Kawamura, Akie Morimoto, Yasuharu Nakahara, Yoshiro Mochizuki, Kentaroh Miyoshi, Takahiro Oto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Diffuse panbronchiolitis (DPB) is a chronic respiratory disease that mainly involves the respiratory bronchioles, and has historically been associated with a very poor prognosis. The development of long-term low dose macrolide therapy in the 1980s has dramatically improved the prognosis of DPB. Nevertheless, some cases are resistant to macrolide therapy, and ultimately develop severe respiratory failure and pulmonary hypertension; in such cases lung transplantation is a viable treatment option. Here we report the case of a 40-year-old patient with a 20-year history of DPB, who underwent bilateral lung transplantation due to severe respiratory failure with pulmonary hypertension.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalRespiratory Investigation
Volume53
Issue number5
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Brain-dead donor
  • Chronic sinusitis
  • Diffuse panbronchiolitis
  • Lung transplantation
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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