A case of corticobasal degeneration that progressed from primary progressive aphasia

Takeshi Kawarabayashi, Etsuro Matsubara, Isao Nagano, Mikio Shoji, Koji Abe

Research output: Contribution to journalArticle

Abstract

A 65-year-old woman began to experience slowly progressive speech disturbance from 2001. She was admitted to our hospital for examination on May 2003. She had dysprosody, paragraphia, and mild disturbance in comprehension of spoken language. Repetition was preserved. No clear paraphasia was found. Calculation was disturbed, but there were no other neurological abnormalities including apraxia and agnosia. Brain MRI showed atrophy of the left frontal and parietal lobes. 99mTc-ECD SPECT showed decreased blood flow in the left frontal lobe and parietal lobe, especially in the Broca area and supplemental motor cortex. Primary progressive aphasia was diagnosed, because aphasia lasted for 2 years without other neurological deficits, and her daily activity was well preserved. During follow up, facial apraxia appeared from December 2003, and limb apraxia appeared from May 2004, followed by rigidity predominantly in the right upper limb and dementia. She was diagnosed as having corticobasal degeneration (CBD). The second SPECT on December 2004 showed progression of the decrease in cerebral flow at the same area showed by the first SPECT. SPECT is useful examination to predict the progress of the disease because the decrease of blood flow was recognized before the progression to CBD.

Original languageEnglish
Pages (from-to)702-707
Number of pages6
JournalJapanese Journal of Geriatrics
Volume42
Issue number6
Publication statusPublished - Nov 2005

Fingerprint

Primary Progressive Aphasia
Single-Photon Emission-Computed Tomography
Apraxias
Parietal Lobe
Frontal Lobe
Agnosia
Aphasia
Motor Cortex
Upper Extremity
Atrophy
Dementia
Language
Extremities
Brain

Keywords

  • Corticobasal degeneration
  • Pick complex
  • Primary progressive aphasia
  • SPECT
  • Tauopathy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kawarabayashi, T., Matsubara, E., Nagano, I., Shoji, M., & Abe, K. (2005). A case of corticobasal degeneration that progressed from primary progressive aphasia. Japanese Journal of Geriatrics, 42(6), 702-707.

A case of corticobasal degeneration that progressed from primary progressive aphasia. / Kawarabayashi, Takeshi; Matsubara, Etsuro; Nagano, Isao; Shoji, Mikio; Abe, Koji.

In: Japanese Journal of Geriatrics, Vol. 42, No. 6, 11.2005, p. 702-707.

Research output: Contribution to journalArticle

Kawarabayashi, T, Matsubara, E, Nagano, I, Shoji, M & Abe, K 2005, 'A case of corticobasal degeneration that progressed from primary progressive aphasia', Japanese Journal of Geriatrics, vol. 42, no. 6, pp. 702-707.
Kawarabayashi, Takeshi ; Matsubara, Etsuro ; Nagano, Isao ; Shoji, Mikio ; Abe, Koji. / A case of corticobasal degeneration that progressed from primary progressive aphasia. In: Japanese Journal of Geriatrics. 2005 ; Vol. 42, No. 6. pp. 702-707.
@article{b6549167267d446b909ee561de48ce3d,
title = "A case of corticobasal degeneration that progressed from primary progressive aphasia",
abstract = "A 65-year-old woman began to experience slowly progressive speech disturbance from 2001. She was admitted to our hospital for examination on May 2003. She had dysprosody, paragraphia, and mild disturbance in comprehension of spoken language. Repetition was preserved. No clear paraphasia was found. Calculation was disturbed, but there were no other neurological abnormalities including apraxia and agnosia. Brain MRI showed atrophy of the left frontal and parietal lobes. 99mTc-ECD SPECT showed decreased blood flow in the left frontal lobe and parietal lobe, especially in the Broca area and supplemental motor cortex. Primary progressive aphasia was diagnosed, because aphasia lasted for 2 years without other neurological deficits, and her daily activity was well preserved. During follow up, facial apraxia appeared from December 2003, and limb apraxia appeared from May 2004, followed by rigidity predominantly in the right upper limb and dementia. She was diagnosed as having corticobasal degeneration (CBD). The second SPECT on December 2004 showed progression of the decrease in cerebral flow at the same area showed by the first SPECT. SPECT is useful examination to predict the progress of the disease because the decrease of blood flow was recognized before the progression to CBD.",
keywords = "Corticobasal degeneration, Pick complex, Primary progressive aphasia, SPECT, Tauopathy",
author = "Takeshi Kawarabayashi and Etsuro Matsubara and Isao Nagano and Mikio Shoji and Koji Abe",
year = "2005",
month = "11",
language = "English",
volume = "42",
pages = "702--707",
journal = "Japanese Journal of Geriatrics",
issn = "0300-9173",
publisher = "Japan Geriatrics Society",
number = "6",

}

TY - JOUR

T1 - A case of corticobasal degeneration that progressed from primary progressive aphasia

AU - Kawarabayashi, Takeshi

AU - Matsubara, Etsuro

AU - Nagano, Isao

AU - Shoji, Mikio

AU - Abe, Koji

PY - 2005/11

Y1 - 2005/11

N2 - A 65-year-old woman began to experience slowly progressive speech disturbance from 2001. She was admitted to our hospital for examination on May 2003. She had dysprosody, paragraphia, and mild disturbance in comprehension of spoken language. Repetition was preserved. No clear paraphasia was found. Calculation was disturbed, but there were no other neurological abnormalities including apraxia and agnosia. Brain MRI showed atrophy of the left frontal and parietal lobes. 99mTc-ECD SPECT showed decreased blood flow in the left frontal lobe and parietal lobe, especially in the Broca area and supplemental motor cortex. Primary progressive aphasia was diagnosed, because aphasia lasted for 2 years without other neurological deficits, and her daily activity was well preserved. During follow up, facial apraxia appeared from December 2003, and limb apraxia appeared from May 2004, followed by rigidity predominantly in the right upper limb and dementia. She was diagnosed as having corticobasal degeneration (CBD). The second SPECT on December 2004 showed progression of the decrease in cerebral flow at the same area showed by the first SPECT. SPECT is useful examination to predict the progress of the disease because the decrease of blood flow was recognized before the progression to CBD.

AB - A 65-year-old woman began to experience slowly progressive speech disturbance from 2001. She was admitted to our hospital for examination on May 2003. She had dysprosody, paragraphia, and mild disturbance in comprehension of spoken language. Repetition was preserved. No clear paraphasia was found. Calculation was disturbed, but there were no other neurological abnormalities including apraxia and agnosia. Brain MRI showed atrophy of the left frontal and parietal lobes. 99mTc-ECD SPECT showed decreased blood flow in the left frontal lobe and parietal lobe, especially in the Broca area and supplemental motor cortex. Primary progressive aphasia was diagnosed, because aphasia lasted for 2 years without other neurological deficits, and her daily activity was well preserved. During follow up, facial apraxia appeared from December 2003, and limb apraxia appeared from May 2004, followed by rigidity predominantly in the right upper limb and dementia. She was diagnosed as having corticobasal degeneration (CBD). The second SPECT on December 2004 showed progression of the decrease in cerebral flow at the same area showed by the first SPECT. SPECT is useful examination to predict the progress of the disease because the decrease of blood flow was recognized before the progression to CBD.

KW - Corticobasal degeneration

KW - Pick complex

KW - Primary progressive aphasia

KW - SPECT

KW - Tauopathy

UR - http://www.scopus.com/inward/record.url?scp=30344469656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30344469656&partnerID=8YFLogxK

M3 - Article

C2 - 16408518

AN - SCOPUS:30344469656

VL - 42

SP - 702

EP - 707

JO - Japanese Journal of Geriatrics

JF - Japanese Journal of Geriatrics

SN - 0300-9173

IS - 6

ER -