Abstract
We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of doubleactivating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations.
| Original language | English |
|---|---|
| Article number | hyr113 |
| Pages (from-to) | 1138-1141 |
| Number of pages | 4 |
| Journal | Japanese Journal of Clinical Oncology |
| Volume | 41 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2011 |
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Keywords
- Activating EGFR mutation
- Erlotinib
- PNA-LNA clamp method
- Rectal cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Radiology Nuclear Medicine and imaging
Cite this
A case of colorectal cancer with double-activating epidermal growth factor receptor mutations. / Rai, Kanmei; Fujiwara, Keiichi; Tsushima, Mizuho; Kudo, Kenichiro; Mizuta, Makoto; Matsuo, Kiyoshi; Yonei, Toshiro; Yamadori, Ichiro; Kiura, Katsuyuki; Sato, Toshio.
In: Japanese Journal of Clinical Oncology, Vol. 41, No. 9, hyr113, 09.2011, p. 1138-1141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of colorectal cancer with double-activating epidermal growth factor receptor mutations
AU - Rai, Kanmei
AU - Fujiwara, Keiichi
AU - Tsushima, Mizuho
AU - Kudo, Kenichiro
AU - Mizuta, Makoto
AU - Matsuo, Kiyoshi
AU - Yonei, Toshiro
AU - Yamadori, Ichiro
AU - Kiura, Katsuyuki
AU - Sato, Toshio
PY - 2011/9
Y1 - 2011/9
N2 - We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of doubleactivating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations.
AB - We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of doubleactivating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations.
KW - Activating EGFR mutation
KW - Erlotinib
KW - PNA-LNA clamp method
KW - Rectal cancer
UR - http://www.scopus.com/inward/record.url?scp=80052452472&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052452472&partnerID=8YFLogxK
U2 - 10.1093/jjco/hyr113
DO - 10.1093/jjco/hyr113
M3 - Article
C2 - 21835826
AN - SCOPUS:80052452472
VL - 41
SP - 1138
EP - 1141
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 9
M1 - hyr113
ER -