A case of colorectal cancer with double-activating epidermal growth factor receptor mutations

Kammei Rai, Keiichi Fujiwara, Mizuho Tsushima, Kenichiro Kudo, Makoto Mizuta, Kiyoshi Matsuo, Toshiro Yonei, Ichiro Yamadori, Katsuyuki Kiura, Toshio Sato

Research output: Contribution to journalArticle

Abstract

We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of doubleactivating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations.

Original languageEnglish
Article numberhyr113
Pages (from-to)1138-1141
Number of pages4
JournalJapanese journal of clinical oncology
Volume41
Issue number9
DOIs
Publication statusPublished - Sep 1 2011

Keywords

  • Activating EGFR mutation
  • Erlotinib
  • PNA-LNA clamp method
  • Rectal cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'A case of colorectal cancer with double-activating epidermal growth factor receptor mutations'. Together they form a unique fingerprint.

  • Cite this

    Rai, K., Fujiwara, K., Tsushima, M., Kudo, K., Mizuta, M., Matsuo, K., Yonei, T., Yamadori, I., Kiura, K., & Sato, T. (2011). A case of colorectal cancer with double-activating epidermal growth factor receptor mutations. Japanese journal of clinical oncology, 41(9), 1138-1141. [hyr113]. https://doi.org/10.1093/jjco/hyr113