A case of bronchostenosis in the allograft after lung transplantation in pulmonary lymphangioleiomyomatosis

Chiyoko Kono, Tetsuo Yamaguchi, Yoshihito Yamada, Sakuo Hoshi, Hiroko Amano, Masato Minami, Shinichiro Miyoshi, Hikari Matsuda, Koichiro Tatsumi, Takayuki Kuriyama

Research output: Contribution to journalArticle

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Abstract

Pulmonary lymphangioleiomyomatosis (LAM) is a rare disease characterized by hamartomatous proliferation of abnormal smooth muscle cells in the lungs. Recently, severe LAM has been listed as an indicated disease for lung transplantation. A 34-yr-old woman with severe pulmonary cystic changes in a chest CT scan was diagnosed as having an isolated form of pulmonary LAM without genetic disorders. Despite intensive progesterone treatment, her pulmonary functions deteriorated rapidly. In January 2001, a left single-lung transplantation was performed from a cadaveric donor. The total operating time was 8 hours and 47 minutes. Total ischemic time was 5 hours and 59 minutes, which was within the permitted time limit. Except for right pneumothorax, the postoperative course was fairly good without any sign of rejection or infection in the allograft. For about two months after transplantation, bronchostenosis occurred in the left lower lobe bronchus, and necessitated a stent placement. During the following three months, stenosis of the bronchi in the anastomotic and peripheral sites occurred repeatedly, which also necessitated stent placement or balloon dilations on each occasion. Despite all the intensive treatment, the bronchostenosis of the peripheral sites still remains and improvement of her pulmonary functions has been poor. Moreover, a recent chest CT scan revealed a progression of the disease in the native lung. Consequently, we registered her as a candidate for transplantation of the right lung. Bronchostenosis should be kept in mind as a complication of lung transplantation.

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume42
Issue number2
Publication statusPublished - 2004
Externally publishedYes

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Lymphangioleiomyomatosis
Lung Transplantation
Allografts
Lung
Bronchi
Stents
Thorax
Inborn Genetic Diseases
Pneumothorax
Rare Diseases
Smooth Muscle Myocytes
Progesterone
Disease Progression
Dilatation
Pathologic Constriction
Transplantation
Tissue Donors
Therapeutics
Infection

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A case of bronchostenosis in the allograft after lung transplantation in pulmonary lymphangioleiomyomatosis. / Kono, Chiyoko; Yamaguchi, Tetsuo; Yamada, Yoshihito; Hoshi, Sakuo; Amano, Hiroko; Minami, Masato; Miyoshi, Shinichiro; Matsuda, Hikari; Tatsumi, Koichiro; Kuriyama, Takayuki.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 42, No. 2, 2004, p. 170-175.

Research output: Contribution to journalArticle

Kono, C, Yamaguchi, T, Yamada, Y, Hoshi, S, Amano, H, Minami, M, Miyoshi, S, Matsuda, H, Tatsumi, K & Kuriyama, T 2004, 'A case of bronchostenosis in the allograft after lung transplantation in pulmonary lymphangioleiomyomatosis', Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, vol. 42, no. 2, pp. 170-175.
Kono, Chiyoko ; Yamaguchi, Tetsuo ; Yamada, Yoshihito ; Hoshi, Sakuo ; Amano, Hiroko ; Minami, Masato ; Miyoshi, Shinichiro ; Matsuda, Hikari ; Tatsumi, Koichiro ; Kuriyama, Takayuki. / A case of bronchostenosis in the allograft after lung transplantation in pulmonary lymphangioleiomyomatosis. In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2004 ; Vol. 42, No. 2. pp. 170-175.
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