Abstract
A 67-year-old woman was diagnosed with ileocolic Crohn's disease at 61 years of age. Remission had been induced by the monoclonal antibody adalimumab, and maintenance therapy had continued since her diagnosis. However, she developed respiratory symptoms, including a dry cough. A chest CT scan revealed interstitial shadows in the lower pulmonary lobes. Although no sicca symptoms were noted, she was serologically positive for both anti-Sjögren's syndrome-related antigen A and B antibodies, and salivary gland biopsy showed lymphocytic infiltration. Consequently, she was diagnosed as having asymptomatic Sjögren's syndrome. Infection or drug-induced pulmonary disease was considered unlikely, and the interstitial pneumonia was considered an extra-glandular presentation of Sjögren's syndrome. Thus, interstitial shadows, which appear during immunotherapy for Crohn's disease, could indicate asymptomatic Sjögren's syndrome; clinicians should consider this rare clinical picture when assessing such a patient.
| Original language | English |
|---|---|
| Pages (from-to) | 1326-1333 |
| Number of pages | 8 |
| Journal | Japanese Journal of Gastroenterology |
| Volume | 112 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2015 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
A case of asymptomatic Sjögren's syndrome who developed interstitial pneumonia during monoclonal antibody therapy of Crohn's disease. / Kohno, Hiroyuki; Okada, Hiroyuki; Hiraoka, Sakiko; Tanaka, Takehiro.
In: Japanese Journal of Gastroenterology, Vol. 112, No. 7, 01.07.2015, p. 1326-1333.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A case of asymptomatic Sjögren's syndrome who developed interstitial pneumonia during monoclonal antibody therapy of Crohn's disease
AU - Kohno, Hiroyuki
AU - Okada, Hiroyuki
AU - Hiraoka, Sakiko
AU - Tanaka, Takehiro
PY - 2015/7/1
Y1 - 2015/7/1
N2 - A 67-year-old woman was diagnosed with ileocolic Crohn's disease at 61 years of age. Remission had been induced by the monoclonal antibody adalimumab, and maintenance therapy had continued since her diagnosis. However, she developed respiratory symptoms, including a dry cough. A chest CT scan revealed interstitial shadows in the lower pulmonary lobes. Although no sicca symptoms were noted, she was serologically positive for both anti-Sjögren's syndrome-related antigen A and B antibodies, and salivary gland biopsy showed lymphocytic infiltration. Consequently, she was diagnosed as having asymptomatic Sjögren's syndrome. Infection or drug-induced pulmonary disease was considered unlikely, and the interstitial pneumonia was considered an extra-glandular presentation of Sjögren's syndrome. Thus, interstitial shadows, which appear during immunotherapy for Crohn's disease, could indicate asymptomatic Sjögren's syndrome; clinicians should consider this rare clinical picture when assessing such a patient.
AB - A 67-year-old woman was diagnosed with ileocolic Crohn's disease at 61 years of age. Remission had been induced by the monoclonal antibody adalimumab, and maintenance therapy had continued since her diagnosis. However, she developed respiratory symptoms, including a dry cough. A chest CT scan revealed interstitial shadows in the lower pulmonary lobes. Although no sicca symptoms were noted, she was serologically positive for both anti-Sjögren's syndrome-related antigen A and B antibodies, and salivary gland biopsy showed lymphocytic infiltration. Consequently, she was diagnosed as having asymptomatic Sjögren's syndrome. Infection or drug-induced pulmonary disease was considered unlikely, and the interstitial pneumonia was considered an extra-glandular presentation of Sjögren's syndrome. Thus, interstitial shadows, which appear during immunotherapy for Crohn's disease, could indicate asymptomatic Sjögren's syndrome; clinicians should consider this rare clinical picture when assessing such a patient.
UR - http://www.scopus.com/inward/record.url?scp=84953343277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953343277&partnerID=8YFLogxK
U2 - 10.11405/nisshoshi.112.1326
DO - 10.11405/nisshoshi.112.1326
M3 - Article
C2 - 26155865
AN - SCOPUS:84953343277
VL - 112
SP - 1326
EP - 1333
JO - Japanese Journal of Gastroenterology
JF - Japanese Journal of Gastroenterology
SN - 0446-6586
IS - 7
ER -