A case of advanced gastric cancer with liver metastasis completely responding to CPT-11+low-dose 5-FU+CDDP chemotherapy

Shunsuke Kagawa, Toshiyoshi Fujiwara, Naoyuki Tokunaga, Masahiko Nishizaki, Futoshi Uno, Fuminori Teraishi, Akira Gouchi, Junji Matsuoka, Noriaki Tanaka

Research output: Contribution to journalArticle

Abstract

The case was a 54-year-old man with type-3 gastric cancer in the cardia accompanied by multiple liver metastasis. He received combination chemotherapy consisting of CPT-11 (60 mg/body, day 1 and 8)+low-dose 5-FU and CDDP (5-FU 500 mg/body/day and CDDP 5 mg/body/day, day 1-5 and 8-12, continuous infusion) every 3 weeks. The initial 2 courses were administered on an inpatient basis,and further courses as an outpatient. After 7 courses of therapy without severe adverse events, not only primary lesion but also hepatic metastasis disappeared. He has been free from disease for 4 months, and chemotherapy was further continued with TS-1 (100 mg/body, day 1-14)+CPT-11 60 mg/body, day 1, 8), every 3 weeks. CPT-11 in combination with low-dose 5-FU+CDDP can be one of the most effective regimens for unresectable advanced gastric cancer.

Original languageEnglish
Pages (from-to)1317-1320
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume33
Issue number9
Publication statusPublished - Sep 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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