A case of adenocarcinoma of the lung associated with giant emphysematous bulla treated with simultaneous cisplatin, 5-fluorouracil, and hyperfractionated thoracic irradiation

Takuji Kitajima, Hiroshi Ueoka, Katsuyuki Kiura, Masahiro Tabata, Mine Harada, Nobuyoshi Shimizu

Research output: Contribution to journalArticle


A 48-year-old man was referred to us, of a mass shadow in the infected emphysematous bulla by chest CT scannings. Neither bronchofiberscopic examination nor CT-guided transcutaneous biopsy could yielded a definitive diagnosis. By surgical resection of the extrapleural tumor directly invading the chest wall, poorly differentiated adenocarcinoma was diagnosed. Three cycles of chemotherapy consisting of cisplatin (20mg/m2 x 5 days) and 5- fluorouracil (500mg/m2 x 5 days), and simultaneous hyperfractionated thoracic irradiation (70Gy in a total dose with 1.25Gy x 2, day) were immediately started and the mass shadow markedly regressed. Lung cancer with a coexisting bulla is frequently advanced and considered to have poor prognosis. Chemoradiotherapy may be useful for the treatment of unresectable advanced cases.

Original languageEnglish
Pages (from-to)913-917
Number of pages5
JournalJapanese Journal of Lung Cancer
Issue number6
Publication statusPublished - Oct 1997
Externally publishedYes



  • Chemo-radiotherapy
  • Giant emphysematous bulla
  • Lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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