TY - JOUR
T1 - A case of acquired hemophilia a diagnosed in conjunction with oral bleeding
AU - Yanagi, Eriko
AU - Kishi, Toshiyuki
AU - Matsumura, Takao
AU - Tani, Yoshinori
AU - Miyahara, Nobuaki
PY - 2016
Y1 - 2016
N2 - Acquired hemophilia A is a rare disease in which autoantibodies to factor VIII are present. It is often manifested as a sudden onset of a critical bleeding episode, and its incidence is reported to be 1.48 cases per million persons per year. We report herein on a case of acquired hemophilia A associated with a submucosal hematoma of the oral floor, pharynx, and larynx. A 78-year-old male presented with fresh bleeding from his mouth, associated with hematoma of the oral floor, pharynx, and larynx. Laboratory test showed that the activated partial thromboplastin time was prolonged, and the platelet count and prothrombin time were normal. Coagulation tests revealed decreased factor VIII levels, and the presence of factor VIII inhibitor. A diagnosis of acquired hemophilia A was made, and immunotherapy with corticosteroids was initiated. After treatment, the bleeding tendency was controlled. On hospital day 29, the symptoms disappeared. Although acquired hemophilia A is a rare coagulopathic condition, it should be considered as one of the differential diagnoses in a case of sudden onset of severe hemorrhagic tendency of unknown origin.
AB - Acquired hemophilia A is a rare disease in which autoantibodies to factor VIII are present. It is often manifested as a sudden onset of a critical bleeding episode, and its incidence is reported to be 1.48 cases per million persons per year. We report herein on a case of acquired hemophilia A associated with a submucosal hematoma of the oral floor, pharynx, and larynx. A 78-year-old male presented with fresh bleeding from his mouth, associated with hematoma of the oral floor, pharynx, and larynx. Laboratory test showed that the activated partial thromboplastin time was prolonged, and the platelet count and prothrombin time were normal. Coagulation tests revealed decreased factor VIII levels, and the presence of factor VIII inhibitor. A diagnosis of acquired hemophilia A was made, and immunotherapy with corticosteroids was initiated. After treatment, the bleeding tendency was controlled. On hospital day 29, the symptoms disappeared. Although acquired hemophilia A is a rare coagulopathic condition, it should be considered as one of the differential diagnoses in a case of sudden onset of severe hemorrhagic tendency of unknown origin.
KW - Acquired hemophilia
KW - Factor VIII inhibitor
KW - Laryngeal hematoma
KW - Oral bleeding
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U2 - 10.3950/jibiinkoka.119.1133
DO - 10.3950/jibiinkoka.119.1133
M3 - Article
C2 - 30051687
AN - SCOPUS:84986237855
VL - 119
SP - 1133
EP - 1136
JO - Journal of Otolaryngology of Japan
JF - Journal of Otolaryngology of Japan
SN - 0030-6622
IS - 8
ER -