TY - JOUR
T1 - A case-control study of lung cancer screening in Okayama Prefecture, Japan
AU - Nishii, Kenji
AU - Ueoka, Hiroshi
AU - Kiura, Katsuyuki
AU - Kodani, Tsuyoshi
AU - Tabata, Masahiro
AU - Shibayama, Takuo
AU - Gemba, Kenichi
AU - Kitajima, Takushi
AU - Hiraki, Akio
AU - Kawaraya, Masashi
AU - Nakayama, Tomio
AU - Harada, Mine
N1 - Funding Information:
We would like to thank Dr Suzuki of Osaka Medical Center for Cancer and Cardiovascular Diseases, and Dr Kawamura of the Okayama Cancer Registry for data collection. We also thank Ms Masakage and Ms Tanaka for their assistance with collection and analysis of data. This study was supported by Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare, Japan (9–7).
PY - 2001
Y1 - 2001
N2 - The effectiveness of lung cancer screening in reducing mortality still remains uncertain. In order to evaluate the efficacy of lung cancer screening, a case-control study was conducted in Okayama Prefecture, Japan. The study area consisted of 34 municipalities where a population-based lung cancer screening had been conducted. Chest X-ray examinations for all participants and sputum cytology for high-risk participants were offered annually. The cases analyzed in this study consisted of 412 individuals aged between 40 and 79 who died of lung cancer. A total of 3490 controls, two to ten for each case matched by gender, year of birth, and living district were randomly collected. Screening histories of cases were compared with those of and matched controls for the identical calendar period prio to diagnosis of the case. Smoking adjusted odds ratio (OR) of death from lung cancer for screened individuals versus unscreened, within 12 months before diagnosis, was calculated as 0.59 (95% confidence interval: 0.46-0.74; P=0.0001). The OR for women (0.39, 95% confidence interval: 0.24-0.64) was lower than that for men (0.67, 95% confidence interval: 0.51-0.87), although both were statistically significant. These results suggest that lung cancer screening contributes to reducing lung cancer mortality by 41%.
AB - The effectiveness of lung cancer screening in reducing mortality still remains uncertain. In order to evaluate the efficacy of lung cancer screening, a case-control study was conducted in Okayama Prefecture, Japan. The study area consisted of 34 municipalities where a population-based lung cancer screening had been conducted. Chest X-ray examinations for all participants and sputum cytology for high-risk participants were offered annually. The cases analyzed in this study consisted of 412 individuals aged between 40 and 79 who died of lung cancer. A total of 3490 controls, two to ten for each case matched by gender, year of birth, and living district were randomly collected. Screening histories of cases were compared with those of and matched controls for the identical calendar period prio to diagnosis of the case. Smoking adjusted odds ratio (OR) of death from lung cancer for screened individuals versus unscreened, within 12 months before diagnosis, was calculated as 0.59 (95% confidence interval: 0.46-0.74; P=0.0001). The OR for women (0.39, 95% confidence interval: 0.24-0.64) was lower than that for men (0.67, 95% confidence interval: 0.51-0.87), although both were statistically significant. These results suggest that lung cancer screening contributes to reducing lung cancer mortality by 41%.
KW - Case-control study
KW - Chest X-ray examination
KW - Lung cancer mortality
KW - Lung cancer screening
KW - Odds ratio
KW - Sputum cytology
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U2 - 10.1016/S0169-5002(01)00270-7
DO - 10.1016/S0169-5002(01)00270-7
M3 - Article
C2 - 11714529
AN - SCOPUS:0034760074
VL - 34
SP - 325
EP - 332
JO - Lung Cancer
JF - Lung Cancer
SN - 0169-5002
IS - 3
ER -