A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells

Akifumi Mizutani, Ling Chen, Tomonari Kasai, Takayuki Kudoh, Hiroshi Murakami, Li Fu, Masaharu Seno

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Appropriate model cell lines recapitulating cancer stem cell (CSC) properties would accelerate not only investigation of cancer stem cells but also development of new clinical cancer therapy by establishing a screening system for anti-cancer stem cell agents. In this chapter, the authors introduce their recent work and others to generate cells with cancer stem cell properties in vitro. They also discuss the concept of cancer stem cells with results obtained from originally established cancer stem-like cells. Finally, they describe future applications of the model to basic and clinical studies. In the field of regeneration therapy, the pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are promising sources of differentiated cells for transplantation. Interestingly, these cancer stem-like cells were not required to be introduced with the genes for cell surface markers that are commonly used to characterize and isolate cancer stem cells.

Original languageEnglish
Title of host publicationCancer Stem Cells
PublisherWiley Blackwell
Pages79-87
Number of pages9
ISBN (Print)9781118356203, 9781118356166
DOIs
Publication statusPublished - Apr 14 2014

Fingerprint

Induced Pluripotent Stem Cells
Neoplastic Stem Cells
Stem cells
Pluripotent Stem Cells
Cell Transplantation
Embryonic Stem Cells
Regeneration
Screening
Genes
Cells
Cell Line
Therapeutics

Keywords

  • Cancer stem cell (CSC) model
  • Cancer stem-like cells
  • Embryonic stem cells (ESCs)
  • Induced pluripotent stem cells
  • Induced pluripotent stem cells (iPSCs)
  • Regeneration therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A Cancer Stem Cell Model : An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells. / Mizutani, Akifumi; Chen, Ling; Kasai, Tomonari; Kudoh, Takayuki; Murakami, Hiroshi; Fu, Li; Seno, Masaharu.

Cancer Stem Cells. Wiley Blackwell, 2014. p. 79-87.

Research output: Chapter in Book/Report/Conference proceedingChapter

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