Abstract
In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 361-367 |
| Number of pages | 7 |
| Journal | International Archives of Allergy and Applied Immunology |
| Volume | 70 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 1983 |
ASJC Scopus subject areas
- Immunology and Allergy
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Hirashima, M., Hirotsu, Y., Yoshimura, T., & Hayashi, H. (1983). A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs. International Archives of Allergy and Applied Immunology, 70(4), 361-367. https://doi.org/10.1159/000233348