A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs

M. Hirashima; Y. Hirotsu; T. Yoshimura; H. Hayashi

doi:10.1159/000233348

A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs

M. Hirashima, Y. Hirotsu, T. Yoshimura, H. Hayashi

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.

Original language	English
Pages (from-to)	361-367
Number of pages	7
Journal	International Archives of Allergy and Applied Immunology
Volume	70
Issue number	4
DOIs	https://doi.org/10.1159/000233348
Publication status	Published - 1983

ASJC Scopus subject areas

Immunology and Allergy

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title = "A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs",

abstract = "In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.",

author = "M. Hirashima and Y. Hirotsu and T. Yoshimura and H. Hayashi",

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doi = "10.1159/000233348",

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T1 - A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs

AU - Hirashima, M.

AU - Hirotsu, Y.

AU - Yoshimura, T.

AU - Hayashi, H.

PY - 1983

Y1 - 1983

N2 - In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.

AB - In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.

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A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs

Abstract

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