Abstract
In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 361-367 |
| Number of pages | 7 |
| Journal | International Archives of Allergy and Applied Immunology |
| Volume | 70 |
| Issue number | 4 |
| Publication status | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Allergy
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A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs. / Hirashima, M.; Hirotsu, Y.; Yoshimura, Teizo; Hayashi, H.
In: International Archives of Allergy and Applied Immunology, Vol. 70, No. 4, 1983, p. 361-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs
AU - Hirashima, M.
AU - Hirotsu, Y.
AU - Yoshimura, Teizo
AU - Hayashi, H.
PY - 1983
Y1 - 1983
N2 - In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.
AB - In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020679019&partnerID=8YFLogxK
M3 - Article
C2 - 6337964
AN - SCOPUS:0020679019
VL - 70
SP - 361
EP - 367
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 4
ER -