A C5-derived macrophage chemotactic factor from DNP-ascaris extract-induced skin lesion in guinea pigs

M. Hirashima, Y. Hirotsu, T. Yoshimura, H. Hayashi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In complement-depleted condition induced by cobra venom factor (CoF, tissue macrophage reaction and macrophage chemotactic activity (MCA) in skin extract from skin lesions induced by DNP-Ascaris extract (DNP-As) were decreased, respectively. MCA in the fraction containing macrophage chemotactic factor b (B fraction) was decreased completely. While MCA in the fraction containing macrophage chemotactic factor a and c (A fraction) was affected only slightly. These results suggested that the decrease of MCA of B-fraction might be associated with depletion of complement system by CoF. Using anti-C5 antibody, it was confirmed that macrophage chemotactic factor-b (MCF-b) (MW 14,000: thermostable) might be derived from C5 fragment in vivo.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalInternational Archives of Allergy and Applied Immunology
Volume70
Issue number4
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy

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