A biophysical perspective of the regulatory mechanisms of ezrin/radixin/moesin proteins

Yosuke Senju, Feng Ching Tsai

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Many signal transductions resulting from ligand–receptor interactions occur at the cell surface. These signaling pathways play essential roles in cell polarization, membrane morphogenesis, and the modulation of membrane tension at the cell surface. However, due to the large number of membrane-binding proteins, including actin-membrane linkers, and transmembrane proteins present at the cell surface, the molecular mechanisms underlying the regulation at the cell surface are yet unclear. Here, we describe the molecular functions of one of the key players at the cell surface, ezrin/radixin/moesin (ERM) proteins from a biophysical point of view. We focus our discussion on biophysical properties of ERM proteins revealed by using biophysical tools in live cells and in vitro reconstitution systems. We first describe the structural properties of ERM proteins and then discuss the interactions of ERM proteins with PI(4,5)P2 and the actin cytoskeleton. These properties of ERM proteins revealed by using biophysical approaches have led to a better understanding of their physiological functions in cells and tissues.

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalBiophysical Reviews
Volume14
Issue number1
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Actin cytoskeleton
  • Ezrin/radixin/moesin proteins
  • GUVs
  • Membrane tension
  • Phosphatidylinositol 4,5-bisphosphate
  • Supported lipid bilayers

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology

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