A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta

M. Noda, T. Asai, Toshinori Shimanouchi, K. Yamashita, H. Umakoshi, M. Okuyama, R. Kubo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages342-344
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Externally publishedYes
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: Nov 1 2009Nov 5 2009

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period11/1/0911/5/09

Fingerprint

Liposomes
Amyloid
Proteins
Serum Amyloid A Protein
Microsensors
Bolometers
Sensors
Fluorescence
Temperature

Keywords

  • Amyloid beta
  • Bio-thermochemical
  • Liposome
  • Microbolometer

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Noda, M., Asai, T., Shimanouchi, T., Yamashita, K., Umakoshi, H., Okuyama, M., & Kubo, R. (2009). A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 342-344). Chemical and Biological Microsystems Society.

A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. / Noda, M.; Asai, T.; Shimanouchi, Toshinori; Yamashita, K.; Umakoshi, H.; Okuyama, M.; Kubo, R.

Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. p. 342-344.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Noda, M, Asai, T, Shimanouchi, T, Yamashita, K, Umakoshi, H, Okuyama, M & Kubo, R 2009, A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. in Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 342-344, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, Korea, Republic of, 11/1/09.
Noda M, Asai T, Shimanouchi T, Yamashita K, Umakoshi H, Okuyama M et al. A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2009. p. 342-344
Noda, M. ; Asai, T. ; Shimanouchi, Toshinori ; Yamashita, K. ; Umakoshi, H. ; Okuyama, M. ; Kubo, R. / A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. pp. 342-344
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