A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta

Minoru Noda, Takeshi Asai, Kaoru Yamashita, Toshinori Shimanouchi, Hiroshi Umakoshi, Masanori Okuyama, Ryouichi Kuboi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Forming process of liposome droplet and its stable immobilization on a Si-based microbolometer are investigated and applied for detection of causative protein of Alzheimer's disease, amyloid β (Aβ) protein, where the disease is closely related to the amyloid fibril formation. This work is a preliminary but innovative approach applying a bio-thermochemical microsensor to monitor the formation. It is observed that the bolometer surface keeps a long time intact behavior of the liposome up to 24 hours. It seems from time course results with Aβ that the variation in the temperature profile corresponds to that observed in fluorescence analysis result of the formation.

Original languageEnglish
Title of host publicationProceedings of IEEE Sensors
Pages836-839
Number of pages4
DOIs
Publication statusPublished - 2009
Externally publishedYes
EventIEEE Sensors 2009 Conference - SENSORS 2009 - Christchurch, New Zealand
Duration: Oct 25 2009Oct 28 2009

Other

OtherIEEE Sensors 2009 Conference - SENSORS 2009
CountryNew Zealand
CityChristchurch
Period10/25/0910/28/09

Fingerprint

Liposomes
Proteins
Microsensors
Bolometers
Sensors
Fluorescence
Temperature
Amyloid

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Noda, M., Asai, T., Yamashita, K., Shimanouchi, T., Umakoshi, H., Okuyama, M., & Kuboi, R. (2009). A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. In Proceedings of IEEE Sensors (pp. 836-839). [5398264] https://doi.org/10.1109/ICSENS.2009.5398264

A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. / Noda, Minoru; Asai, Takeshi; Yamashita, Kaoru; Shimanouchi, Toshinori; Umakoshi, Hiroshi; Okuyama, Masanori; Kuboi, Ryouichi.

Proceedings of IEEE Sensors. 2009. p. 836-839 5398264.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Noda, M, Asai, T, Yamashita, K, Shimanouchi, T, Umakoshi, H, Okuyama, M & Kuboi, R 2009, A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. in Proceedings of IEEE Sensors., 5398264, pp. 836-839, IEEE Sensors 2009 Conference - SENSORS 2009, Christchurch, New Zealand, 10/25/09. https://doi.org/10.1109/ICSENS.2009.5398264
Noda, Minoru ; Asai, Takeshi ; Yamashita, Kaoru ; Shimanouchi, Toshinori ; Umakoshi, Hiroshi ; Okuyama, Masanori ; Kuboi, Ryouichi. / A bio-thermochemical sensor of microbolometer immobilized liposome for detection of causative protein of Alzheimer's disease, amyloid beta. Proceedings of IEEE Sensors. 2009. pp. 836-839
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