A bio-thermochemical microbolometer with immobilized intact liposome on sensor solid surface

M. Noda, T. Shimanouchi, M. Okuyama, R. Kuboi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have developed a scheme of bio-thermochemical microbolometer with immobilized intact liposome on sensor solid surface. A liposome of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was confirmed to be deposited intact by X-ray diffraction (XRD) and AFM analysis on a Pt film that is used as resistive bolometer material. By using a fabricated surface micromachined thermal cavity structure beneath the Pt resistor film with the immobilized intact liposome, thermochemical reactions of DPPC on phase transition among gel, ripple and fluid phases have been successfully detected. It is also found from analysis of fluorescence polarization that endothermic reaction especially at around 40 °C (phase change from ripple to fluid) corresponds to the change in mobility of phospholipid molecule. As a result we believe that the developed scheme of the microbolometer is effective for detecting thermochemical reaction of biochemical molecules that interact with the liposome.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume135
Issue number1
DOIs
Publication statusPublished - Dec 10 2008
Externally publishedYes

Keywords

  • Bio-thermochemical
  • DPPC
  • Fluorescence polarization
  • Immobilization
  • Liposome
  • Microbolometer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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