A 6-year survival case of locally advanced unresectable pancreatic tail cancer treated with chemo-radiation therapy

Hiroyoshi Matsukawa, Shigehiro Shiozaki, Norihisa Takakura, Hideki Aoki, Yasuhiro Fujiwara, Satoshi Ohno, Yasutomo Ojima, Masao Harano, Masahiko Nishizaki, Yasuhiro Choda, Motoki Ninomiya

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a case of locally advanced unresectable pancreatic tail cancer patient who survived over 6 years by chemo-radiation therapy (CRT). A 61 -year-old male was pointed out by CT to have pancreatic tail cancer of 5.6 cm in diameter that invaded to the stomach, left kidney and adrenal gland, nerve plexus of celiac and superior mesenteric artery, was diagnosed as locally advanced unresectable pancreatic tail cancer. CRT of gemcitabine (GEM) with RT to a primary lesion was successful. After two years and 11 months, Schnitzler's metastasis appeared and RT was effective to recover from rectal stricture. At three years and 3 months, GEM was converted to S-1. After 4 years and 5 months, paraaortic lymph node metastasis was enlarged, so chemotherapy was changed to combination of GEM + S-1. After 4 years and 10 months, upper mediastinal lymph node metastasis appeared. At 6 years and 1 month, RT to upper mediastinum for pain control was performed. Finally, 6 years and 6 months after the first diagnosis, he died of pancreatic cancer. A long-term survival of locally advanced unresectable pancreatic cancer is very rare. In the case of pancreatic cancer that CRT is effective to the remission of primary lesion, CRT is potentially useful to perform for the control of metastatic lesion or palliative therapy.

Original languageEnglish
Pages (from-to)2355-2357
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume37
Issue number12
Publication statusPublished - Nov 2010
Externally publishedYes

Fingerprint

gemcitabine
Pancreatic Neoplasms
Radiotherapy
Survival
Neoplasm Metastasis
Lymph Nodes
Celiac Plexus
Superior Mesenteric Artery
Mediastinum
Adrenal Glands
Palliative Care
Stomach
Pathologic Constriction
Kidney
Drug Therapy
Pain

Keywords

  • Chemo-radiation therapy
  • Locally advanced unresectable pancreatic cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Matsukawa, H., Shiozaki, S., Takakura, N., Aoki, H., Fujiwara, Y., Ohno, S., ... Ninomiya, M. (2010). A 6-year survival case of locally advanced unresectable pancreatic tail cancer treated with chemo-radiation therapy. Gan to kagaku ryoho. Cancer & chemotherapy, 37(12), 2355-2357.

A 6-year survival case of locally advanced unresectable pancreatic tail cancer treated with chemo-radiation therapy. / Matsukawa, Hiroyoshi; Shiozaki, Shigehiro; Takakura, Norihisa; Aoki, Hideki; Fujiwara, Yasuhiro; Ohno, Satoshi; Ojima, Yasutomo; Harano, Masao; Nishizaki, Masahiko; Choda, Yasuhiro; Ninomiya, Motoki.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 37, No. 12, 11.2010, p. 2355-2357.

Research output: Contribution to journalArticle

Matsukawa, H, Shiozaki, S, Takakura, N, Aoki, H, Fujiwara, Y, Ohno, S, Ojima, Y, Harano, M, Nishizaki, M, Choda, Y & Ninomiya, M 2010, 'A 6-year survival case of locally advanced unresectable pancreatic tail cancer treated with chemo-radiation therapy', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 37, no. 12, pp. 2355-2357.
Matsukawa, Hiroyoshi ; Shiozaki, Shigehiro ; Takakura, Norihisa ; Aoki, Hideki ; Fujiwara, Yasuhiro ; Ohno, Satoshi ; Ojima, Yasutomo ; Harano, Masao ; Nishizaki, Masahiko ; Choda, Yasuhiro ; Ninomiya, Motoki. / A 6-year survival case of locally advanced unresectable pancreatic tail cancer treated with chemo-radiation therapy. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2010 ; Vol. 37, No. 12. pp. 2355-2357.
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