@article{72af9f69f3de4d1daab34bfed40a275a,
title = "Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane",
abstract = "The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.",
keywords = "Alzheimer's disease, Amyloid β/Cu Complex, Cholesterol, Domain, Liposome",
author = "Toshinori Shimanouchi and Makoto Tasaki and Vu, {Huong Thi} and Haruyuki Ishii and Noriko Yoshimoto and Hiroshi Umakoshi and Ryoichi Kuboi",
note = "Funding Information: The authors would thank Mr. Dane Cohen for his experimental contribution. The authors also thank the group of Engineering Science of Liposome and International Seminar between Japan Society for the Promotion of Science (JSPS)-Swiss National Scientific Foundation (SNSF) for the helpful discussion. The author would also thank the group of Membrane Stress Biotechnology. This work was partly supported by Grants-in-Aid for Scientist Research (no.21246121, 20760539, 20360350, 19656220, 19656203) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. This work was also partly supported by the Core University Program between JSPS and Vietnamese Academy of Science and Technology (VAST). It was partly supported by the Global COE program “Bio-Environmental Chemistry” of JSPS. The authors also thank the Gas Hydrate Analyzing System of Osaka University. H. Ishii also thanks the JSPS-Fellowship.",
year = "2010",
month = feb,
doi = "10.1016/j.jbiosc.2009.08.003",
language = "English",
volume = "109",
pages = "145--148",
journal = "Journal of Bioscience and Bioengineering",
issn = "1389-1723",
publisher = "The Society for Biotechnology, Japan",
number = "2",
}