Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane

Toshinori Shimanouchi; Makoto Tasaki; Huong Thi Vu; Haruyuki Ishii; Noriko Yoshimoto; Hiroshi Umakoshi; Ryoichi Kuboi

doi:10.1016/j.jbiosc.2009.08.003

Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane

Toshinori Shimanouchi, Makoto Tasaki, Huong Thi Vu, Haruyuki Ishii, Noriko Yoshimoto, Hiroshi Umakoshi, Ryoichi Kuboi

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Journal of Bioscience and Bioengineering
Volume	109
Issue number	2
DOIs	https://doi.org/10.1016/j.jbiosc.2009.08.003
Publication status	Published - Feb 1 2010
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid β/Cu Complex
Cholesterol
Domain
Liposome

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

Access to Document

10.1016/j.jbiosc.2009.08.003

Fingerprint Dive into the research topics of 'Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane'. Together they form a unique fingerprint.

Cite this

Shimanouchi, T., Tasaki, M., Vu, H. T., Ishii, H., Yoshimoto, N., Umakoshi, H., & Kuboi, R. (2010). Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane. Journal of Bioscience and Bioengineering, 109(2), 145-148. https://doi.org/10.1016/j.jbiosc.2009.08.003

@article{72af9f69f3de4d1daab34bfed40a275a,

title = "Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane",

abstract = "The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.",

keywords = "Alzheimer's disease, Amyloid β/Cu Complex, Cholesterol, Domain, Liposome",

author = "Toshinori Shimanouchi and Makoto Tasaki and Vu, {Huong Thi} and Haruyuki Ishii and Noriko Yoshimoto and Hiroshi Umakoshi and Ryoichi Kuboi",

year = "2010",

month = feb,

day = "1",

doi = "10.1016/j.jbiosc.2009.08.003",

language = "English",

volume = "109",

pages = "145--148",

journal = "Journal of Bioscience and Bioengineering",

issn = "1389-1723",

publisher = "The Society for Biotechnology, Japan",

number = "2",

}

TY - JOUR

T1 - Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane

AU - Shimanouchi, Toshinori

AU - Tasaki, Makoto

AU - Vu, Huong Thi

AU - Ishii, Haruyuki

AU - Yoshimoto, Noriko

AU - Umakoshi, Hiroshi

AU - Kuboi, Ryoichi

PY - 2010/2/1

Y1 - 2010/2/1

N2 - The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.

AB - The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.

KW - Alzheimer's disease

KW - Amyloid β/Cu Complex

KW - Cholesterol

KW - Domain

KW - Liposome

UR - http://www.scopus.com/inward/record.url?scp=74049162948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74049162948&partnerID=8YFLogxK

U2 - 10.1016/j.jbiosc.2009.08.003

DO - 10.1016/j.jbiosc.2009.08.003

M3 - Article

C2 - 20129098

AN - SCOPUS:74049162948

VL - 109

SP - 145

EP - 148

JO - Journal of Bioscience and Bioengineering

JF - Journal of Bioscience and Bioengineering

SN - 1389-1723

IS - 2

ER -