Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane

Toshinori Shimanouchi; Makoto Tasaki; Huong Thi Vu; Haruyuki Ishii; Noriko Yoshimoto; Hiroshi Umakoshi; Ryoichi Kuboi

doi:10.1016/j.jbiosc.2009.08.003

Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane

Toshinori Shimanouchi, Makoto Tasaki, Huong Thi Vu, Haruyuki Ishii, Noriko Yoshimoto, Hiroshi Umakoshi, Ryoichi Kuboi

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Journal of Bioscience and Bioengineering
Volume	109
Issue number	2
DOIs	https://doi.org/10.1016/j.jbiosc.2009.08.003
Publication status	Published - Feb 1 2010
Externally published	Yes

Keywords

Alzheimer's disease
Amyloid β/Cu Complex
Cholesterol
Domain
Liposome

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane. / Shimanouchi, Toshinori; Tasaki, Makoto; Vu, Huong Thi; Ishii, Haruyuki; Yoshimoto, Noriko; Umakoshi, Hiroshi; Kuboi, Ryoichi.

In: Journal of Bioscience and Bioengineering, Vol. 109, No. 2, 01.02.2010, p. 145-148.

Research output: Contribution to journal › Article › peer-review

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