Abstract
The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.
| Original language | English |
|---|---|
| Pages (from-to) | 145-148 |
| Number of pages | 4 |
| Journal | Journal of Bioscience and Bioengineering |
| Volume | 109 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2010 |
| Externally published | Yes |
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Keywords
- Alzheimer's disease
- Amyloid β/Cu Complex
- Cholesterol
- Domain
- Liposome
ASJC Scopus subject areas
- Biotechnology
- Applied Microbiology and Biotechnology
- Bioengineering
Cite this
Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane. / Shimanouchi, Toshinori; Tasaki, Makoto; Vu, Huong Thi; Ishii, Haruyuki; Yoshimoto, Noriko; Umakoshi, Hiroshi; Kuboi, Ryoichi.
In: Journal of Bioscience and Bioengineering, Vol. 109, No. 2, 02.2010, p. 145-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aβ/Cu-catalyzed oxidation of cholesterol in 1,2-dipalmitoyl phosphatidylcholine liposome membrane
AU - Shimanouchi, Toshinori
AU - Tasaki, Makoto
AU - Vu, Huong Thi
AU - Ishii, Haruyuki
AU - Yoshimoto, Noriko
AU - Umakoshi, Hiroshi
AU - Kuboi, Ryoichi
PY - 2010/2
Y1 - 2010/2
N2 - The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.
AB - The amyloid β protein with 42 amino acid residues (Aβ), which is a causative protein of Alzheimer's disease (AD), forms the complex with copper (II) to induce the cholesterol oxidase-like activity by the proton transfer from the cholesterol. In this study, the oxidation of cholesterol by Aβ/Cu complex was investigated on the surface of the zwitterionic phospholipid liposome including the bound water advantageous for the enhancement of the proton transfer. The bound water was pooled by the formation of cholesterol-rich domain within liposomes. The resulting reactivity was enhanced by the proton transfer mediated by the bound water.
KW - Alzheimer's disease
KW - Amyloid β/Cu Complex
KW - Cholesterol
KW - Domain
KW - Liposome
UR - http://www.scopus.com/inward/record.url?scp=74049162948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74049162948&partnerID=8YFLogxK
U2 - 10.1016/j.jbiosc.2009.08.003
DO - 10.1016/j.jbiosc.2009.08.003
M3 - Article
C2 - 20129098
AN - SCOPUS:74049162948
VL - 109
SP - 145
EP - 148
JO - Journal of Bioscience and Bioengineering
JF - Journal of Bioscience and Bioengineering
SN - 1389-1723
IS - 2
ER -