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  • Shinichi Toyooka
2020

Antitumor effects of pan-raf inhibitor LY3009120 against lung cancer cells harboring oncogenic BRAF mutation

Miyauchi, S., Shien, K., Takeda, T., Araki, K., Nakata, K., Miura, A., Takahashi, Y., Kurihara, E., Ogoshi, Y., Namba, K., Suzawa, K., Yamamoto, H., Okazaki, M., Sou, J., Tomida, S., Yamane, M., Sakaguchi, M. & Toyooka, S., May 2020, In : Anticancer research. 40, 5, p. 2667-2673 7 p.

Research output: Contribution to journalArticle

Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer

Fukuma, S., Shinya, T., Sou, J., Fukuhara, R., Ogawa, N., Higaki, F., Tanaka, T., Ichihara, E., Hiraki, T., Toyooka, S. & Kanazawa, S., Apr 1 2020, In : Acta medica Okayama. 74, 2, p. 129-135 7 p.

Research output: Contribution to journalArticle

Chemoradiation therapy for non-small cell lung cancer exacerbates thoracic aortic calcification determined by computed tomography

Miki, T., Miyauchi, S., Miyoshi, T., Yoshida, M., Ichikawa, K., Soh, J., Nakamura, K., Kiura, K., Kanazawa, S., Toyooka, S. & Ito, H., Jan 1 2020, (Accepted/In press) In : Heart and Vessels.

Research output: Contribution to journalArticle

DV200 Index for Assessing RNA Integrity in Next-Generation Sequencing

Matsubara, T., Sou, J., Morita, M., Uwabo, T., Tomida, S., Fujiwara, T., Kanazawa, S., Toyooka, S. & Hirasawa, A., Jan 1 2020, In : BioMed research international. 2020, 9349132.

Research output: Contribution to journalArticle

Open Access

Evaluation of Therapeutic Target Gene Expression Based on Residual Cancer Burden Classification After Neoadjuvant Chemotherapy for HER2-Negative Breast Cancer

Takahashi, Y., Iwamoto, T., Suzuki, Y., Kajiwara, Y., Hatono, M., Tsukioki, T., Kawada, K., Kochi, M., Ikeda, H., Shien, T., Taira, N., Matsuoka, J., Doihara, H. & Toyooka, S., Apr 2020, In : Clinical Breast Cancer. 20, 2, p. 117-124.e4

Research output: Contribution to journalArticle

Influence of breast density on breast cancer risk: a case control study in Japanese women

Nishiyama, K., Taira, N., Mizoo, T., Kochi, M., Ikeda, H., Iwamoto, T., Shien, T., Doihara, H., Ishihara, S., Kawai, H., Kawasaki, K., Ishibe, Y., Ogasawara, Y. & Toyooka, S., Mar 1 2020, In : Breast Cancer. 27, 2, p. 277-283 7 p.

Research output: Contribution to journalArticle

Influences of preoperative metformin on immunological factors in early breast cancer

Tsukioki, T., Shien, T., Tanaka, T., Suzuki, Y., Kajihara, Y., Hatono, M., Kawada, K., Kochi, M., Iwamoto, T., Ikeda, H., Taira, N., Doihara, H. & Toyooka, S., Jan 1 2020, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

Open Access

MAPK pathway alterations correlate with poor survival and drive resistance to therapy in patients with lung cancers driven by ROS1 fusions

Sato, H., Schoenfeld, A. J., Siau, E., Lu, Y. C., Tai, H., Suzawa, K., Kubota, D., Lui, A. J. W., Qeriqi, B., Mattar, M., Offin, M., Sakaguchi, M., Toyooka, S., Drilon, A., Rosen, N. X., Kris, M. G., Solit, D., de Stanchina, E., Davare, M. A., Riely, G. J. & 2 others, Ladanyi, M. & Somwar, R., Jun 15 2020, In : Clinical Cancer Research. 26, 12, p. 2932-2945 14 p.

Research output: Contribution to journalArticle

Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma

Koshimune, S., Kosaka, M., Mizuno, N., Yamamoto, H., Miyamoto, T., Ebisui, K., Toyooka, S. & Ohtsuka, A., Jun 5 2020, In : BMC cancer. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Open Access
Open Access

Warm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine model

Irie, M., Otani, S., Kurosaki, T., Tanaka, S., Ohki, T., Miyoshi, K., Sugimoto, S., Yamane, M., Oto, T. & Toyooka, S., Apr 1 2020, In : General Thoracic and Cardiovascular Surgery. 68, 4, p. 363-369 7 p.

Research output: Contribution to journalArticle

YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers

Takeda, T., Yamamoto, H., Suzawa, K., Tomida, S., Miyauchi, S., Araki, K., Nakata, K., Miura, A., Namba, K., Shien, K., Sou, J., Shien, T., Kitamura, Y., Sendo, T. & Toyooka, S., Mar 1 2020, In : Cancer Science. 111, 3, p. 849-856 8 p.

Research output: Contribution to journalArticle

Open Access

ゲノム医療におけるデータサイエンティストの役割と育成

Translated title of the contribution: Training medical Staš with basic skills for data science in genomic medicineTomida, S., Morita, M., Yamashita, N., Hirasawa, A. & Toyooka, S., May 1 2020, In : Yakugaku Zasshi. 140, 5, p. 657-661 5 p.

Research output: Contribution to journalArticle

Open Access
2019

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

Yoshioka, T., Shien, K., Takeda, T., Takahashi, Y., Kurihara, E., Ogoshi, Y., Namba, K., Torigoe, H., Sato, H., Tomida, S., Yamamoto, H., Soh, J., Fujiwara, T. & Toyooka, S., Jan 1 2019, In : Cancer Science. 110, 8, p. 2549-2557 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Activation of AXL as a preclinical acquired resistance mechanism against osimertinib treatment in EGFR-mutant non-small cell lung cancer cells

Namba, K., Shien, K., Takahashi, Y., Torigoe, H., Sato, H., Yoshioka, T., Takeda, T., Kurihara, E., Ogoshi, Y., Yamamoto, H., Sou, J., Tomida, S. & Toyooka, S., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 499-507 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Anti-tumor effect of neratinib against lung cancer cells harboring HER2 oncogene alterations

Ogoshi, Y., Shien, K., Yoshioka, T., Torigoe, H., Sato, H., Sakaguchi, M., Tomida, S., Namba, K., Kurihara, E., Takahashi, Y., Suzawa, K., Yamamoto, H., Soh, J. & Toyooka, S., Mar 2019, In : Oncology Letters. 17, 3, p. 2729-2736 8 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

Namba, K., Tomida, S., Matsubara, T., Takahashi, Y., Kurihara, E., Ogoshi, Y., Yoshioka, T., Takeda, T., Torigoe, H., Sato, H., Shien, K., Yamamoto, H., Soh, J., Tsukuda, K. & Toyooka, S., Feb 26 2019, In : BMC cancer. 19, 1, 175.

Research output: Contribution to journalArticle

Open Access

A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY)

Ninomiya, K., Hata, T., Yoshioka, H., Ohashi, K., Bessho, A., Hosokawa, S., Ishikawa, N., Yamasaki, M., Shibayama, T., Aoe, K., Kozuki, T., Harita, S., Ueda, Y., Murakami, T., Fujimoto, N., Yanai, H., Toyooka, S., Takata, M., Hotta, K., Kiura, K. & 108 others, Gemba, K., Ikeda, G., Yasugi, M., Kurimoto, E., Nakano, K., Moritaka, T., Inoue, K., Miyoshi, S., Hamaguchi, N., Ito, R., Sano, Y., Takata, I., Mitani, A., Nishisaka, T., Shoda, H., Nishida, A., Tamamoto, S., Fujitaka, K., Masuda, T., Miyamoto, S., Hattori, N., Sugimoto, K., Fujii, S., Ueda, Y., Sakugawa, M., Fukamatsu, N., Ogata, Y., Bandoh, S., Kanaji, N., Takigawa, N., Yamane, H., Ochi, N., Honda, Y., Oka, M., Kittaka, M., Kubota, T., Yokoyama, A., Yokoyama, T., Sato, E., Shiota, Y., Horita, N., Kanematsu, T., Awaya, Y., Nakamasu, A., Murakami, I., Kuyama, S., Kudo, K., Tamura, T., Umeno, T., Morichika, D., Fujiwara, K., Sato, K., Harada, D., Nogami, N., Nishii, K., Fuchimoto, Y., Kishimoto, T., Kawai, H., Watanabe, K., Tokumo, K., Isobe, T., Tsubata, Y., Inoue, M., Ichikawa, H., Nishioka, Y., Hanibuchi, M., Goto, H., Sumikawa, T., Kodani, M., Suyama, H., Makino, H., Kinosita, N., Shimizu, E., Obata, H., Ikegami, H., Chikamori, K., Maeda, T., Kishino, T., Kamei, H., Ueoka, H., Kunihiro, Y., Kobayashi, T., Ueda, K., Hayashi, M., Kamiya, M., Murakami, J., Sato, A., Ichihara, E., Kubo, T., Ninomiya, T., Hirata, T., Minami, D., Kato, Y., Higo, H., Makimoto, G., Toyota, Y., Oda, N., Nakanishi, M., Kayatani, H., Senoo, S., Kano, H., Watanabe, H., Ando, T., Nakasuka, T., Hara, N., Itano, J., Nakashima, H. & Tabata, M., Aug 2019, In : Chest. 156, 2, p. 357-366 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Clinical outcome of patients with recurrent non-small cell lung cancer after trimodality therapy

Suzawa, K., Soh, J., Takahashi, Y., Sato, H., Shien, K., Yamamoto, H., Kanazawa, S., Kiura, K., Miyoshi, S. & Toyooka, S., Jul 10 2019, In : Surgery today. 49, 7, p. 601-609 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Correction to: Risk assessments for broncho-pleural fistula and respiratory failure after lung cancer surgery by National Clinical Database Japan (General Thoracic and Cardiovascular Surgery, (2019), 67, 3, (297-305), 10.1007/s11748-018-1022-y)

Endo, S., Ikeda, N., Kondo, T., Nakajima, J., Kondo, H., Shimada, Y., Sato, M., Toyooka, S., Okada, Y., Sato, Y., Yoshino, I., Okada, M., Okumura, M., Chida, M., Fukuchi, E. & Miyata, H., Oct 1 2019, In : General Thoracic and Cardiovascular Surgery. 67, 10, p. 904-906 3 p.

Research output: Contribution to journalComment/debate

Open Access

Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness

Chen, Y., Sumardika, I. W., Tomonobu, N., Kinoshita, R., Inoue, Y., Iioka, H., Mitsui, Y., Saito, K., Ruma, I. M. W., Sato, H., Yamauchi, A., Murata, H., Yamamoto, K. I., Tomida, S., Shien, K., Yamamoto, H., Soh, J., Futami, J., Kubo, M., Putranto, E. W. & 7 others, Murakami, T., Liu, M., Hibino, T., Nishibori, M., Kondo, E., Toyooka, S. & Sakaguchi, M., Jul 2019, In : Neoplasia (United States). 21, 7, p. 627-640 14 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
9 Citations (Scopus)

Detection of lung cancer cells using a terahertz chemical microscope

Sato, K., Iida, M., Inoue, H., Kiwa, T., Toyooka, S. & Tsukada, K., Jan 1 2019, JSAP-OSA Joint Symposia, JSAP_2019. OSA - The Optical Society, (Optics InfoBase Conference Papers; vol. Part F146-JSAP 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access

Droplet digital PCR as a novel system for the detection of microRNA‑34b/c methylation in circulating DNA in malignant pleural mesothelioma

Sato, H., Sou, J., Aoe, K., Fujimoto, N., Tanaka, S., Namba, K., Torigoe, H., Shien, K., Yamamoto, H., Tomida, S., Tao, H., Okabe, K., Kishimoto, T. & Toyooka, S., Jun 1 2019, In : International journal of oncology. 54, 6, p. 2139-2148 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis

Kinoshita, R., Sato, H., Yamauchi, A., Takahashi, Y., Inoue, Y., Sumardika, I. W., Chen, Y., Tomonobu, N., Araki, K., Shien, K., Tomida, S., Torigoe, H., Namba, K., Kurihara, E., Ogoshi, Y., Murata, H., Yamamoto, K., Futami, J., Putranto, E. W., Ruma, I. M. W. & 7 others, Yamamoto, H., Sou, J., Hibino, T., Nishibori, M., Kondo, E., Toyooka, S. & Sakaguchi, M., Jun 15 2019, In : International Journal of Cancer. 144, 12, p. 3138-3145 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers

Takamatsu, H., Yamamoto, K. I., Tomonobu, N., Murata, H., Inoue, Y., Yamauchi, A., Wayan Sumardika, I., Chen, Y., Kinoshita, R., Yamamura, M., Fujiwara, H., Mitsui, Y., Araki, K., Futami, J., Saito, K., Iioka, H., Made Winarsa Ruma, I., Putranto, E. W., Nishibori, M., Kondo, E. & 3 others, Yamamoto, Y., Toyooka, S. & Sakaguchi, M., Jan 1 2019, In : Oncology research. 27, 6, p. 713-727 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Feasibility of lung transplantation from donors mechanically ventilated for prolonged periods

Sugimoto, S., Kurosaki, T., Otani, S., Tanaka, S., Hikasa, Y., Yamane, M., Toyooka, S., Kobayashi, M. & Oto, T., Mar 8 2019, In : Surgery today. 49, 3, p. 254-260 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Final overall survival results of WJTOG3405, a randomized phase III trial comparing gefitinib versus cisplatin with docetaxel as the first-line treatment for patients with stage IIIB/IV or postoperative recurrent EGFR mutation-positive non-small-cell lung cancer

Yoshioka, H., Shimokawa, M., Seto, T., Morita, S., Yatabe, Y., Okamoto, I., Tsurutani, J., Satouchi, M., Hirashima, T., Atagi, S., Shibata, K., Saito, H., Toyooka, S., Yamamoto, N., Nakagawa, K. & Mitsudomi, T., Dec 1 2019, In : Annals of Oncology. 30, 12, p. 1978-1984 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer

Kurihara, E., Shien, K., Torigoe, H., Takeda, T., Takahashi, Y., Ogoshi, Y., Yoshioka, T., Namba, K., Sato, H., Suzawa, K., Yamamoto, H., Sou, J., Okazaki, M., Shien, T., Tomida, S. & Toyooka, S., Apr 1 2019, In : Anticancer research. 39, 4, p. 1767-1775 9 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Impact of pathological stage and histological subtype on clinical outcome of adjuvant chemotherapy of paclitaxel plus carboplatin versus oral uracil–tegafur for non-small cell lung cancer: subanalysis of SLCG0401 trial

Soh, J., Toyooka, S., Okumura, N., Nakamura, H., Nakata, M., Yamashita, M., Sakamoto, J., Aoe, M., Hotta, K., Morita, S. & Date, H., Nov 1 2019, In : International Journal of Clinical Oncology. 24, 11, p. 1367-1376 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
1 Citation (Scopus)

Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion

Chen, Y., Sumardika, I. W., Tomonobu, N., Winarsa Ruma, I. M., Kinoshita, R., Kondo, E., Inoue, Y., Sato, H., Yamauchi, A., Murata, H., Yamamoto, K., Tomida, S., Shien, K., Yamamoto, H., Sou, J., Liu, M., Futami, J., Sasai, K., Katayama, H., Kubo, M. & 6 others, Putranto, E. W., Hibino, T., Sun, B., Nishibori, M., Toyooka, S. & Sakaguchi, M., Jun 28 2019, In : Cancer Letters. 452, p. 178-190 13 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Mortality from extrathymic malignancy after thymic tumour resections: Incidences and risk factors

Hamaji, M., Sozu, T., MacHida, R., Watanabe, S. I., Yoshida, K., Toyooka, S., Tanahashi, M., Kondo, K., Horio, H., Okumura, M. & Date, H., Nov 1 2019, In : Interactive cardiovascular and thoracic surgery. 29, 5, p. 729-736 8 p.

Research output: Contribution to journalArticle

Open Access

Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression

Sumardika, I. W., Chen, Y., Tomonobu, N., Kinoshita, R., Ruma, I. M. W., Sato, H., Kondo, E., Inoue, Y., Yamauchi, A., Murata, H., Yamamoto, K., Tomida, S., Shien, K., Yamamoto, H., Sou, J., Futami, J., Putranto, E. W., Hibino, T., Nishibori, M., Toyooka, S. & 1 others, Sakaguchi, M., Jan 1 2019, In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Pulmonary resection in a prone position for lung cancer invading the spine

Miyauchi, S., Sou, J., Shien, K., Tanaka, M., Yamamoto, H., Ozaki, T. & Toyooka, S., Jan 1 2019, (Accepted/In press) In : General Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle