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Author

  • Masaharu Takigawa
2020

Antiparkinson drug benztropine suppresses tumor growth, circulating tumor cells, and metastasis by acting on SLC6A3/dat and reducing STAT3

Sogawa, C., Eguchi, T., Tran, M. T., Ishige, M., Trin, K., Okusha, Y., Taha, E. A., Lu, Y., Kawai, H., Sogawa, N., Takigawa, M., Calderwood, S. K., Okamoto, K. & Kozaki, K. I., Feb 2020, In : Cancers. 12, 2, 523.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction

Ohkawara, B., Kobayakawa, A., Kanbara, S., Hattori, T., Kubota, S., Ito, M., Masuda, A., Takigawa, M., Lyons, K. M., Ishiguro, N. & Ohno, K., Jan 1 2020, (Accepted/In press) In : EMBO Reports.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
Open Access

Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS-2/8 Chondrosarcoma Cells

Shield, W. P., Cellini, A., Tian, H., Wilson, K., Dan, Y., Abzug, J. M., Garcia, S., Moritani, N., Alferiev, I., Chorny, M., Takigawa, M., Ng, V. Y., Iwamoto, M. & Enomoto-Iwamoto, M., May 1 2020, In : Journal of Orthopaedic Research. 38, 5, p. 1045-1051 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
2019

A Reporter System Evaluates Tumorigenesis, Metastasis, β-catenin/MMP Regulation, and Druggability

Sogawa, C., Eguchi, T., Okusya, Y., Ono, K., Ohyama, K., Iizuka, M., Kawasaki, R., Hamada, Y., Takigawa, M., Sogawa, N., Okamoto, K. & Kozaki, K. I., Oct 1 2019, In : Tissue Engineering - Part A. 25, 19-20, p. 1413-1425 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi

Ohta, K., Aoyama, E., Ahmad, S. A. I., Ito, N., Anam, M. B., Kubota, S. & Takigawa, M., Mar 1 2019, In : Journal of Cell Communication and Signaling. 13, 1, p. 113-118 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells

Shoji, M., Ueda, M., Nishioka, M., Minato, H., Seki, M., Harada, K., Kubo, M., Fukuyama, Y., Suzuki, Y., Aoyama, E., Takigawa, M. & Kuzuhara, T., Nov 5 2019, In : Biochemical and Biophysical Research Communications. 519, 2, p. 309-315 7 p.

Research output: Contribution to journalArticle

Open Access

Possible reparative effect of low-intensity pulsed ultrasound (LIPUS) on injured meniscus

Kamatsuki, Y., Aoyama, E., Furumatsu, T., Miyazawa, S., Maehara, A., Yamanaka, N., Nishida, T., Kubota, S., Ozaki, T. & Takigawa, M., Jun 6 2019, In : Journal of Cell Communication and Signaling. 13, 2, p. 193-207 15 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation

Nishida, T., Kubota, S., Yokoi, H., Mukoyama, M. & Takigawa, M., Dec 1 2019, In : Scientific reports. 9, 1, 10913.

Research output: Contribution to journalArticle

Open Access
2018

Depletion of lipid efflux pump ABCG1 triggers the intracellular accumulation of extracellular vesicles and reduces aggregation and tumorigenesis of metastatic cancer cells

Namba, Y., Sogawa, C., Okusya, Y., Kawai, H., Itagaki, M., Ono, K., Murakami, J., Aoyama, E., Ohyama, K., Asaumi, J-I., Takigawa, M., Okamoto, K., Calderwood, S. K., Kozaki, K. I. & Eguchi, T., Oct 10 2018, In : Frontiers in Oncology. 8, OCT, 376.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling

Matsumoto, K., Shimo, T., Kurio, N., Okui, T., Ibaragi, S., Kunisada, Y., Obata, K., Masui, M., Pai, P., Horikiri, Y., Yamanaka, N., Takigawa, M. & Sasaki, A., Jun 1 2018, In : Journal of Cellular Biochemistry. 119, 6, p. 4352-4360 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Metabolic regulation of the CCN family genes by glycolysis in chondrocytes

Akashi, S., Nishida, T., El-Seoudi, A., Takigawa, M., Iida, S. & Kubota, S., Mar 1 2018, In : Journal of Cell Communication and Signaling. 12, 1, p. 245-252 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

Eguchi, T., Sogawa, C., Okusha, Y., Uchibe, K., Iinuma, R., Ono, K., Nakano, K., Murakami, J., Itoh, M., Arai, K., Fujiwara, T., Namba, Y., Murata, Y., Ohyama, K., Shimomura, M., Okamura, H., Takigawa, M., Nakatsura, T., Kozaki, K. I., Okamoto, K. & 1 others, Calderwood, S. K., Feb 2018, In : PloS one. 13, 2, e0191109.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Physiological role of urothelial cancer-associated one long noncoding RNA in human skeletogenic cell differentiation

Ishikawa, T., Nishida, T., Ono, M., Takarada, T., Nguyen, H. T., Kurihara, S., Furumatsu, T., Murase, Y., Takigawa, M., Oohashi, T., Kamioka, H. & Kubota, S., Jun 2018, In : Journal of cellular physiology. 233, 6, p. 4825-4840 16 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The BMP-2 mutant L51P: a BMP receptor IA binding-deficient inhibitor of noggin

Khattab, H. M., Kubota, S., Takigawa, M., Kuboki, T. & Sebald, W., Apr 17 2018, (Accepted/In press) In : Journal of Bone and Mineral Metabolism. p. 1-7 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Analysis of expression of CCN family genes in skeletal tissue-derived cells

Kawaki, H., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 33-41 9 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Analysis of pathological activities of CCN proteins in bone metastasis

Shimo, T., Yoshioka, N., Takigawa, M. & Sasaki, A., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 505-512 8 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Analysis of posttranscriptional regulation of CCN genes

Kondo, S., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 187-209 23 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Analysis of signaling pathways activated by CCN proteins

Kawaki, H., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 139-143 5 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Analysis of transcytosis of CCN2 by chondrocytes

Kawata, K., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 405-413 9 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

An early history of CCN2/CTGF research: the road to CCN2 via hcs24, ctgf, ecogenin, and regenerin

Takigawa, M., Oct 26 2017, (Accepted/In press) In : Journal of Cell Communication and Signaling. p. 1-12 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
7 Citations (Scopus)

Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis

El-Seoudi, A., Abd El Kader, T., Nishida, T., Eguchi, T., Aoyama, E., Takigawa, M. & Kubota, S., Sep 1 2017, In : Journal of Cell Communication and Signaling. 11, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cell biological assays for measuring angiogenic activities of CCN proteins

Shimo, T. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 239-249 11 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Cell biological assays for measuring chondrogenic activities of CCN2 protein

Nishida, T., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 219-237 19 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Elisa of CCN family proteins in body fluids including serum and plasma

Kubota, S., Kawaki, H. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 127-138 12 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Erratum: Proinsulin C-peptide regulates ribosomal RNA expression (The Journal of Biological Chemistry (2010) 285 (3462-3469) DOI: 10.1074/jbc.M109.053587)

Lindahl, E., Nyman, U., Zaman, F., Palmberg, C., Cascante, A., Shafqat, J., Takigawa, M., Sävendahl, L., Jörnvall, H. & Joseph, B., Mar 10 2017, In : Journal of Biological Chemistry. 292, 10, 1 p.

Research output: Contribution to journalComment/debate

Evaluation of molecular interaction between CCN2 protein and its binding partners by surface plasmon resonance (SPR)

Aoyama, E. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 169-176 8 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Gene expression analysis of CCN proteins: Whole-mount in situ hybridization of Ccn2 in developing calcified tissues

Yamaai, T. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 11-19 9 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Generation and analysis of cartilage-specific CCN2 overexpression in transgenic mice

Hattori, T., Itoh, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 391-403 13 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunohistochemical analysis of CCN proteins in calcified tissues

Kawaki, H., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 53-62 10 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

In vitro transfection with and expression of CCN family of genes

Janune, D. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 107-113 7 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Preparation of module-specific antibodies against CCN family members

Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 115-128 14 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Production of recombinant CCN2 protein by mammalian cells

Nishida, T., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 95-105 11 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Production of recombinant CCN2 protein in Escherichia coli

Aoyama, E., Hattori, T., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 77-84 8 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Promoter analyses of CCN genes

Eguchi, T., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 177-185 9 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Protein imaging of CCN2 AND CCN3 in living cells

Hattori, T., Hoshijima, M. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 211-215 5 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

Protocols for screening for binding partners of CCN proteins: Yeast two-hybrid system

Hoshijima, M., Hattori, T. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 145-154 10 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Protocols for screening peptide motifs binding to ccn family proteins

Kubota, S., Kawaki, H. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 155-167 13 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
1 Citation (Scopus)

The ccn proteins: An overview

Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 1-8 8 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage- specific manner

Ishikawa, T., Toyama, T., Nakamura, Y., Tamada, K., Shimizu, H., Ninagawa, S., Okada, T., Kamei, Y., Ishikawa-Fujiwara, T., Todo, T., Aoyama, E., Takigawa, M., Harada, A. & Mori, K., Jun 1 2017, In : Journal of Cell Biology. 216, 6, p. 1761-1774 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Western blotting analysis of CCN proteins in calcified tissues

Kawaki, H., Kubota, S. & Takigawa, M., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 43-51 9 p. (Methods in Molecular Biology; vol. 1489).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2016

CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-β3 function

Yoshioka, Y., Ono, M., Maeda, A., Kilts, T. M., Hara, E. S., Khattab, H., Ueda, J., Aoyama, E., Oohashi, T., Takigawa, M., Young, M. F. & Kuboki, T., Feb 1 2016, In : Bone. 83, p. 162-170 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins

Eguchi, T., Calderwood, S. K., Takigawa, M., Kubota, S. & Kozaki, K. I., 2016, (Accepted/In press) In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Involvement of multiple CCN family members in platelets that support regeneration of joint tissues

Hara, C., Kubota, S., Nishida, T., Hiasa, M., Hattori, T., Aoyama, E., Moriyama, Y., Kamioka, H. & Takigawa, M., Nov 1 2016, In : Modern Rheumatology. 26, 6, p. 940-949 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)